Ambrobene solution for inhalation and oral administration. Instructions for use. Ambrobene - instructions for use for children and adults

The site provides reference information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. Consultation with a specialist is required!

Ambrobene refers to chemical preparations that have an expectorant and sputum-thinning effect. The drug has a therapeutic effect in diseases with cough and difficult sputum discharge. The main active ingredient is ambroxol. Ambrobene also has an antioxidant effect: it neutralizes and removes damaging molecules called free radicals from the body.

The drug reduces the viscosity of sputum and facilitates its outflow from the bronchi. Ambrobene works as follows:

the drug stimulates the production of enzymes in the bronchial mucosa that break down the bonds between the substances that make up the sputum;

activates the formation of surfactant (a mixture of active substances that prevent the alveoli of the lungs from sticking together);

activates the function of the cilia of the bronchial mucosa, preventing them from sticking together.

Ambrobene penetrates in the highest concentration into the lung tissue, and can pass into breast milk, through the placental barrier and into the cerebrospinal fluid. The effect after internal administration of the drug is observed within 30 minutes and lasts (depending on the dose) 6-12 hours. After administration as an injection, Ambrobene acts faster and lasts for 6-10 hours. Excreted from the body with urine.

Release forms

Tablets – 30 mg, 20 pieces per package;

Ambrobene retard capsules – 75 mg ambroxol, 10 or 20 pieces per package;

Syrup (3 mg ambroxol in 1 ml) – 100 ml bottles;

Solution for inhalation and internal administration (7.5 mg ambroxol in 1 ml) – bottles of 40 ml and 100 ml;

Solution for injection in ampoules (15 mg ambroxol in 2 ml) – 5 ampoules per package.

Instructions for use

Indications for use

Ambrobene in any dosage form is used for the treatment of chronic and acute respiratory diseases in which there is sputum and its discharge from the respiratory tract is impaired: pneumonia, bronchitis, bronchial asthma, bronchiectasis.

The drug is also used to treat respiratory distress syndrome in newborns (including premature babies) in order to activate the synthesis of surfactant.

Contraindications

individual intolerance to any component of the drug;

peptic ulcer of the duodenum and stomach;

epilepsy and convulsive syndrome;

functional failure of the liver and kidneys;

secretion of sputum in large quantities and impaired bronchial motility due to immobile cilia (due to the threat of stagnation of sputum in the bronchi).

Side effects

From the digestive tract (less than 1%): increased salivation or dry mouth, nausea, vomiting, abdominal pain, bowel dysfunction (constipation or diarrhea).

From the respiratory system (less than 1%): copious nasal discharge, shortness of breath.

Allergic reactions (less than 1%): skin rashes such as urticaria, itching, swelling of the face, fever, anaphylactic shock (isolated cases).
Other reactions (less than 1%): headache, weakness, heaviness in the legs, chills, increased blood pressure, problems with urination.

Ambrobene treatment

How to use Ambrobene?

The drug has no effect on the speed of reaction and attention; there are no professional restrictions during treatment.

Patients diagnosed with diabetes mellitus should take into account that the syrup contains sorbitol as an excipient.

Ambrobene in solution for injection is administered intravenously by drip or slowly in a stream. Before administration, the drug is diluted with saline solution - 0.9% sodium chloride solution, Ringer-Locke solution or 5% dextrose solution.

The solution for internal use is dosed using a measuring cup included with the medicine package.

The use of the drug in the form of inhalations is described below (in the Ambrobene for inhalations section).

Ambrobene dosage

Pills: adults are prescribed 90 mg/day (1 tablet x 3 times) for 2-3 days, and then 30 mg/day (0.5 tablet x 2 times).

Ambrobene retard capsules: adults: 1 capsule (75 mg) per day.

Syrup: adults: 90 mg/day (10 ml x 3 times) for 2-3 days, then 60 mg/day (10 ml x 2 times).

Ambrobene solution inside: for 2-3 days, 90 mg/day (4 ml x 3 times), then 60 mg/day (4 ml x 2 times).

Ambrobene solution for injection: adults 30-45 mg/day (2 ml x 2-3 r.)

For functional disorders of the liver or kidneys, lower doses are used and with increasing intervals between doses of the drug. Only a doctor can prescribe a dosage regimen in these cases.

Overdose

Ambrobene for children

The most convenient dosage form of Ambrobene for treating children is syrup. It is dosed using a plastic measuring cup: 1 ml of syrup contains 3 mg of active ingredient.

Doses of syrup for children

up to 2 years – 15 mg/day (2.5 ml x 2 times);

from 2 to 6 years – 22.5 mg/day (2.5 ml x 3 times);

from 6 to 12 years – 30-45 mg/day (5 ml x 2-3 r.);

over 12 years old - as for adults: 90 mg/day (10 ml x 3 times) for 2-3 days, then 60 mg/day (10 ml x 2 times).

Doses of the drug in tablets

Doses of the drug in capsules for children over 12 years of age

Doses of the drug for children in the form of an oral solution

up to 2 years – 1 ml x 2 times/day;

from 2 to 6 years – 1 ml x 3 rubles/day

from 6 to 12 years – 2 ml x 2-3 rubles/day;

after 12 years - as for adults: 90 mg/day (4 ml x 3 times) for 2-3 days, then 60 mg/day (4 ml x 2 times).

Doses of the drug for children in the form of injections

The dose of the drug is prescribed at the rate of 1.2 -1.6 mg/kg of the baby’s body weight.

Children under 2 years old – 1 ml x 2 times per day;

2-6 years – 1 ml x 3 rubles/day;

after 6 years – 2 ml x 2-3 rubles/day

For respiratory distress syndrome in newborns (including premature babies), the dose of the drug can be increased to 10 mg/kg body weight per day, and even up to 30 mg/kg body weight in severe cases. The daily dose of the medicine is administered 3-4 times a day. Discontinue the drug when symptoms disappear.

The injection solution cannot be combined in the same dropper (or syringe) with medications whose pH is higher than 6.3.

For the use of Ambrobene in the form of inhalations for children, see below in the section “Ambrobene for inhalations”.

For inhalations

Benefits of this treatment: the medicinal substance immediately enters the bronchial mucosa and acts immediately; the drug has a more effective effect, while giving the least number of adverse reactions; Ambrobene inhalations can reduce treatment time and doses of antibacterial drugs.

The drug quickly thins out thick, viscous mucus that impairs the patency of the bronchi. By coughing up sputum after inhalation, the patient feels significant relief. Using Ambrobene inhalations for bronchiectasis, you can achieve longer remission.

The bronchi are cleared of clear, viscous mucus by inhalation after an attack of bronchial asthma. To prevent the occurrence of an attack of bronchospasm provoked by inhalation, the patient is recommended to take bronchial dilators before the procedure.

For Ambrobene inhalation, a solution is used, which can also be used internally. In some cases, simultaneous administration of the drug orally and by inhalation is used, taking into account the daily dose of the drug. The solution is dosed using a measuring cup.

For inhalations, you can use any modern equipment (with the exception of steam inhalations). The most convenient device is a nebulizer, which converts the medicine into an aerosol that can penetrate hard-to-reach areas of the lungs and bronchi. This device is convenient to use both in the hospital and at home.

Before use, the Ambrobene solution is diluted by half with physiological sodium chloride solution and heated to 36-37˚C. The prepared solution is placed in a special container, then the inhaler is turned on. To prevent coughing during inhalation, you should breathe normally and not deeply. You can inhale the medicine using a mask placed on the face or through a special breathing tube (the mouthpiece is placed in the mouth).

Ambrobene dosages for inhalation:

children under 2 years old - 1 ml of Ambrobene solution 1-2 times a day (only under the supervision of a doctor);

children from 2 to 6 years old – 2 ml x 1-2 rubles/day;

children over 6 years old and adults – 2-3 ml x 1-2 r./day.

During pregnancy and lactation

In the second or third trimester of pregnancy, the appointment of Ambrobene is permissible only by the doctor’s decision and in cases where the therapeutic effect is higher than the possible risk of exposure to the fetus.

Given that the drug passes into breast milk, a nursing woman can take the drug as prescribed by a doctor when assessing the balance between the benefits of treatment and the risk for the child.

For dry cough

A dry cough with inflammation in the respiratory organs should be converted to a wet one. This can be achieved with the help of Ambrobene, using any form of release of the drug. The easiest way to achieve the desired effect is through inhalation. Under the influence of ambroxol, the bronchial mucosa produces mucus, the sputum is liquefied and excreted.

In some cases, the cough may be dry even when sputum is in the bronchi, but is not coughed up due to impaired motor activity of the bronchi. In these cases, the use of Ambrobene is not indicated and even poses a danger.

Ambrobene drug interactions

Simultaneous treatment with Ambrobene and other antitussive drugs containing Codeine makes it difficult to produce sputum, because they suppress cough.

Ambrobene improves the accumulation of antibiotics such as Erythromycin, Amoxicillin, Doxycycline, Cefuroxime in the lung tissue and bronchi.

Ambrobene in the form of an injection solution cannot be mixed with solutions whose pH is higher than 6.3.

Analogs

Lazolvan or Ambrobene?

Manufacturers of drugs are different

Ambrobene has more dosage forms than Lazolvan, but at the same time, it also has more contraindications. Lazolvan can be used at any age. Both drugs are not recommended for use during pregnancy or breastfeeding. It is undesirable to prescribe both drugs for a wet cough.

Despite the similar mechanism of action, the drugs differ in the excipients in their composition, which should be taken into account when choosing a drug.
The price of Ambrobene is lower than Lazolvan.

A clear answer to the question “Which is better of these two drugs?” No. The drug is selected by the doctor individually.

Content

When a severe cough haunts you and interferes with work and rest, you really want to find a medicine that will quickly cope with the problem. The task is within the capabilities of a German drug that helps relieve unpleasant symptoms and alleviate the condition. It is important to study the instructions so that use does not cause harm.

Active ingredients of Ambrobene

The drug is characterized by mucolytic properties. After use, a large amount of mucus begins to be produced, which is immediately removed from the nasopharynx, lungs, and bronchi. Ambrobene's instructions inform that the drug normalizes, facilitates breathing, and has the following properties:

anti-inflammatory;
antioxidant;
expectorants.

Ambrobene - the instructions for use are known - is effective due to the properties of the drug. From the beginning of the reception:

the sticking of small alveoli is eliminated;
patency in small bronchi improves;
the movement of epithelial cilia is stimulated, their gluing is prevented, which promotes the removal of mucus;
enzymes are produced that dilute sputum and reduce viscosity;
the production of immunoglobulin is enhanced - local immunity is increased;
harmful bacteria are removed.

The composition of the drug Ambrobene, according to the instructions, depends on the release format - capsules, solution, tablets, but in all cases it contains the main substance - ambroxol hydrochloride. Auxiliary ingredients may be:

magnesium stearate;
silicon dioxide;
corn starch;
potassium sorbate;
sorbitol liquid;
hydrochloric water;
propylene glycol;
saccharin;
raspberry flavor.

Indications for the use of a low-cost mucolytic agent are respiratory diseases. Their peculiarity is the presence of difficult to separate, viscous sputum. Treatable:

tracheobronchitis;
pneumonia;
bronchiectasis;
nasopharyngitis;
bronchitis;
sinusitis;
laryngitis;
pneumoconiosis;
cystic fibrosis of the lungs.

The use of a cheap drug to improve the patient’s condition is effective:

with a dry cold cough during ARVI,
for cleansing the bronchi before and after surgery;
to stimulate lung maturation in a child during the perinatal period;
for bronchial asthma if there is a problem with sputum discharge;
to facilitate the removal of mucus in tuberculosis.

How to use Ambrobene

An important condition, according to the instructions, is to wash down the drug with a large amount of water - at least 100 ml: this helps to better liquefy and remove mucus. The prescribed dosage must be followed. How to take Ambrobene - depends on the release format:

solution - dilute with juice, water;
take a tablet or syrup;
composition for inhalation - breathe;
Effervescent tablets - dissolve in water.

Ambrobene syrup - instructions for use

The pediatric form of the medicine is very convenient. Ambrobene syrup has a pleasant raspberry taste, does not contain thickeners or preservatives - it is safe for children. Available in dark bottles of 100 ml, each 5 ml contains 15 mg of ambroxol. For ease of use there is a measuring cup. The pediatrician prescribes a dosage depending on age:

under 5 years – 2.5 ml per day 2-3 times;
from 5 to 12 – 5 ml three times a day;
after 12 years – 10 ml, 3 times a day.

Solution for oral administration and inhalation - instructions

Medicine used in liquid form works faster. The drug is in a dark 100 ml dropper bottle, equipped with a glass with divisions - it is convenient to take the desired dose. For adults, 4 ml per dose, for children – 2 ml; according to the instructions, use is recommended three times a day. Ambrobene for inhalation is used in dosages selected by the doctor. If you have asthma, take bronchodilators first.

Inhalations for children

With a dry cough, you can quickly alleviate the child's condition by inhaling with a nebulizer. The solution in the form of fine drops reaches the most remote areas of the bronchi and lungs, moisturizing, softening the mucous membrane, and improving expectoration. How to do inhalations with Ambrobene? The process goes like this:

liquid medicine is mixed in equal parts with saline;
pour into container;
breathe freely for 3 minutes;
course – up to 7 days.

Pills

For oral use, popular tablets are available in regular and effervescent forms, as well as gelatin capsules at an affordable price. Drink them after meals, always with water. The medicine is used in different ways:

Ambrobene tablets contain 30 mg of ambroxol and require three times a day;
The capsule has a prolonged action, it contains 75 mg of active substance - this dose is enough for a day.

Application of Ambrobene

Describes in detail how to drink Ambrobene, what to focus on, and instructions for the drug. The following points are important:

the effect of treatment occurs after half an hour, the effect lasts 12 hours;
use of the drug for up to 2 years only as prescribed by a pediatrician;
when practiced simultaneously with antibiotics, their effect is enhanced;
It is not advisable to use without medical supervision for more than 5 days.

When a cough with sputum that is difficult to separate occurs, it is better if the doctor prescribes the dosage, taking into account contraindications, the form of the medicine, and writes down a treatment regimen. Need to know:

the drug should be discontinued if side effects occur;
avoid simultaneous consumption with antitussives;
It is necessary to take the medicine with water.

For what cough should I take it?

The instructions for use note the effect of this drug in the treatment of inflammatory diseases of the respiratory system. For what cough is Ambrobene given? The use of the drug in the presence of viscous, difficult to remove sputum has good reviews from doctors. The drug helps quickly:

thin mucus;
remove it from the body;
improve breathing.

No less effective treatment for dry cough. The use of a medicinal solution in the form of inhalation by adults and children contributes to the appearance of sputum. You feel better when the mucus begins to separate. The cough becomes wet and soft, which alleviates the condition of the following diseases:

colds tracheitis;
pneumonia;
chronic bronchitis.

Contraindications of the drug

Although the medicine can be purchased without a prescription and at an affordable price, it is advisable that the medicine be prescribed by a doctor taking into account the state of health - there are contraindications for use of Ambrobene. Among them are hypersensitivity to the main active substance – ambroxol, as well as:

impaired bronchial motility;
taking antitussive medications;
breastfeeding period.

Abstract Ambrobene stipulates the undesirable use of the medicine in capsule form in children under 12 years of age. Its use is contraindicated when significant secretion is observed, in addition, in the case of:

liver diseases;
epilepsy;
first trimester of pregnancy;
renal dysfunction;
ulcers of the duodenum and stomach.

Ambrobene - side effects

Since there are many good reviews about the drug, and the price is low, there is a desire to use it in self-treatment. The instructions do not recommend this - with incorrect dosage, uncontrolled long-term use, side effects of Ambrobene cannot be ruled out. Possible appearance:

low blood pressure;
allergic dermatitis;
nausea;
diarrhea;
dry mouth;
itching;
constipation;
vomiting;
hives;
increased salivation;
heartburn;
chills;
high temperature;
headache;
Quincke's edema;
anaphylactic shock.

Price

In Russia, the most popular drug is produced by the German company Meckle GmbH, which can be purchased inexpensively at the nearest pharmacy. Capsules, syrup, solution, tablets are sold without a prescription. Alternatively, you can order from an online pharmacy. How much does Ambrobene cost? The average price depends on the release format, trading conditions and is in rubles:

solution, 100 ml – 165 rubles;
capsules, 75 mg, No. 20 – 260 rub.;
syrup, 100 ml – 130 rub.;
tablets, 30 mg, No. 20 – 125 rub..

Ambrobene is a mucolytic and expectorant drug, produced by MERCKLE (Germany) in five dosage forms (tablets, syrup, ampoules, capsules, solutions for inhalation, oral administration). It is allowed, subject to the instructions, to use Ambrobene for children from birth and during pregnancy.

The active component is ambroxol, which is a derivative of the mucolytic bromhexine, exhibits expectorant and mucolytic properties. Ambrobene is produced in tablets, syrup, ampoules, capsules, solutions for inhalation, and oral administration.

Solution– transparent, with a yellowish tint, packaged in bottles with a dropper, the price is 185 rubles per 100 ml.

Capsules– gelatin, with a transparent body, a brownish dense cap, containing ambroxol granules. Ambrobene retard is a long-acting product, the price is 265 rubles.

Pills white, round in shape, scored on one side. The drug is packaged in blisters of 10 pieces, instructions that tell you how to take Ambrobene tablets are included in a pack of blisters, the price of the product is 145 rubles.

Syrup- a yellowish liquid that smells like raspberries. Take after meals with a good glass of water. The syrup moisturizes dry cough, relieves pain, eliminates sore throat, the cost of 100 ml of the product is 130 - 150 rubles.

Ambrobene for injection— in ampoules of 2 ml of darkened glass contains 15 mg of the active ingredient. The injection solution is used in cases where it is necessary to quickly achieve a therapeutic effect.

Indications for use

Ambrobene facilitates the removal of viscous sputum and is used in the treatment of:

pneumonia;
asthma.

In injections, the drug is used for severe respiratory infections to enhance the production of pulmonary surfactant.

Contraindications for use

Ambrobene is prescribed with caution for stomach diseases and lactose intolerance. The medicine is used with caution in cases of pathology of the kidneys and liver.

The drug is contraindicated for stomach ulcers, diseases of the duodenum, epilepsy, and individual intolerance to the drug.

Contraindicated for children:

under 6 years old – take tablets;
under 12 years old - take capsules.

Up to 2 years, the drug is used only with a prescription. At this age, solutions are prescribed for oral administration and administration, strictly following the instructions for use of Ambrobene, using saline solution for dilution.

Instructions for use

During treatment, increase the daily volume of fluid you drink. The mucolytic effect occurs only if there is a sufficient volume of fluid drunk.

Use in children

Application of the solution:

at the age of less than 2 years - drink 1 ml 2 times a day;
2 years - 6 years - 1 ml up to 3 times a day;
after 6 years - 12 - 2 ml drink 3 times a day

Ambrobene syrup dosage for children:

up to 2 years – 2 times/day. 2.5 ml each;
from 2 years – 6 years – drink 2.5 ml up to 3 times a day;
from 6 years - 12 - drink 5 ml up to 3 times a day.

Dosage of Ambrobene tablets: from 6 years of age, 0.5 tablets 3 times a day.

Use in solution (drops) for inhalation in dosage:

children under 2 years old - 1 ml 2 times a day for inhalation;
from 2 years – 6 years – 2 ml inhaled 2 times a day;
children over 6 years old – 3 ml inhaled 2 times a day.

For inhalation, you can use any inhalers, excluding steam ones. For inhalation with a nebulizer, the medicine must be diluted 1:1 with saline; before use, you need to make sure that the solution is at room temperature. Young children can dilute Ambrobene with saline solution 1:2.

Read also how else you can treat bronchitis in children in our articles:

Dosage regimen for adults

For adults, children over 12 years old:

solution - during the initial days of illness, drink 4 ml 3 times a day, further treatment - 4 ml 2 times a day;
inhalation - 3 ml up to 2 times a day;
capsules are taken 1 piece/day;
take one tablet 3 times a day for 3 days of treatment, then the daily dosage is reduced to 1 tablet 2 times a day;
syrup is drunk during the first 3 days of illness, 10 ml 3 times a day, increase the dosage if you feel unwell to 20 ml 2 times a day. For further treatment, drink 10 ml 2 times a day.

Capsules and tablets are washed down with plenty of water and consumed after meals without chewing. Do not take for more than 4 days without a doctor's prescription. The maximum dose of tablets for adults can be increased to 2 tablets 3 times a day.

P No. 014731/02-2003

Tradename: Ambrobene

International nonproprietary name:

ambroxol

Dosage form:

solution for oral administration and inhalation

Compound
100 ml of solution contains:
active substance: ambroxol hydrochloride 0.750 mg
Excipients: potassium sorbate, hydrochloric acid, purified water.

Description
A transparent, colorless to slightly yellowish, odorless solution.

Pharmacotherapeutic group:

mucolytic agent.

ATS code: R05CB06

PHARMACHOLOGIC EFFECT
Ambroxol (the active metabolite of bromhexine) is a mucolytic drug that improves the rheological properties of sputum, reduces its viscosity and adhesive properties, which facilitates its removal from the respiratory tract.
Ambroxol stimulates the activity of the serous cells of the bronchial lining glands, the production of enzymes that break down the bonds between sputum polysaccharides, the formation of surfactant and the direct activity of the bronchial cilia, preventing their adhesion.
After oral administration, the therapeutic effect occurs within 30 minutes and lasts for 6-12 hours (depending on the dose taken).

INDICATIONS FOR USE
Ambrobene - a solution for oral administration and inhalation is used for diseases of the respiratory tract with the release of viscous sputum and difficulty in sputum discharge:
- acute and chronic bronchitis, pneumonia;
- bronchial asthma;
- bronchiectasis.

CONTRAINDICATIONS
- hypersensitivity to ambroxol and/or other components of the finished dosage form;
- peptic ulcer of the stomach and duodenum;
- epileptic syndrome

Relative contraindications
If the functional capacity of the kidneys is limited and/or with severe liver disease, Ambrobene should be taken with extreme caution, reducing the dose used and increasing the time between doses of the drug (usually in these conditions, treatment is carried out under the supervision of a physician).
Ambrobene should also be used with extreme caution and only under the supervision of a physician in cases of impaired bronchial motility and in large volumes of secreted secretions (the risk of stagnation of secretions in the bronchi).

USE DURING PREGNANCY AND BREASTFEEDING
Despite the fact that to date there is no reliable data on the negative effects of ambroxol on the fetus and infants, using Ambrobene during pregnancy, especially in the first trimester, and during breastfeeding is possible only after a thorough analysis of the benefit/risk ratio by the attending physician.

METHOD OF APPLICATION AND DOSES
Oral use:
Ambrobene is taken orally after meals with a sufficient amount of liquid (for example, water, juice or tea) using the supplied measuring cup.
The following dosages are usually used (1 ml of solution contains 7.5 mg of ambroxol):
Children under 2 years old take 1 ml of solution 2 times a day (15 mg/day).
Children from 2 to 6 years old take 1 ml of solution 3 times a day (22.5 mg/day).
Children from 6 to 12 years old take 2 ml of solution 2-3 times a day (30-45 mg/day).
Adults and teenagers in the first 2-3 days of treatment, take 4 ml of solution 3 times a day (90 mg/day), in subsequent days, 4 ml of solution 2 times a day (60 mg/day).
Inhalations:
When using Ambrobene in the form of inhalations, you can use any modern equipment (except for steam inhalations). Before inhalation, the drug is mixed with a 0.9% sodium chloride solution (for optimal air humidification, it can be diluted in a 1:1 ratio) and heated to body temperature. Inhalations should be carried out in normal breathing mode (so as not to provoke coughing shocks). Patients suffering from bronchial asthma, in order to avoid nonspecific irritation of the respiratory tract and their spasm, should use bronchodilators before inhaling ambroxol. The following dosages are usually used (1 ml of solution contains 7.5 mg of ambroxol):
Children under 2 years old inhale 1 ml of solution 1-2 times a day (7.5-15 mg/day).
Children from 2 to 6 years old 2 ml of solution 1-2 times a day (15-30 mg/day).
Children over 6 years old and adults inhale 2-3 ml of solution 1-2 times a day (15-45 mg/day).
Treatment of children under 2 years of age is carried out only under the supervision of a doctor.
While taking Ambrobene, it is recommended to drink plenty of fluids.
It is not recommended to use Ambrobene without medical prescription for more than 4-5 days.

SIDE EFFECT
Occasionally, weakness, headache, dry mouth and respiratory tract, salivation, rhinorrhea, gastralgia, nausea, vomiting, diarrhea, constipation, dysuria, exanthema may develop. In very rare cases, allergic reactions may occur (skin rash, angioedema of the face, breathing problems, temperature reaction with chills). Allergic contact dermatitis has been reported in isolated cases, and anaphylactic shock has been reported in one case.

INTERACTION WITH OTHER MEDICINES
Simultaneous use with drugs that have antitussive activity (for example, containing codeine) is not recommended due to the difficulty of removing sputum from the bronchi while reducing cough.
Simultaneous administration with antibiotics (amoxicillin, cefuroxime, erythromycin, doxycycline) improves the flow of antibiotics into the pulmonary tract. This interaction with doxycycline is widely used for therapeutic purposes.

OVERDOSE
Ambroxol is well tolerated when taken orally at a dose of up to 25 mg/kg per day.
Symptoms: increased salivation, nausea, vomiting, decreased blood pressure.
Treatment: gastric lavage in the first 1-2 hours after taking the drug, taking fat-containing foods; it is necessary to monitor hemodynamic parameters and carry out symptomatic therapy if necessary.

RELEASE FORM
A dark glass bottle containing 40 ml or 100 ml of the drug, with a dropper stopper and a screw cap. 1 bottle with accompanying measuring cup and consumer information in a cardboard box.

STORAGE CONDITIONS
At a temperature not higher than 25°C. Keep out of the reach of children!

BEST BEFORE DATE
5 years.
Do not use after the expiration date stated on the package.

CONDITIONS OF VACATION FROM PHARMACIES
Over the counter.

MANUFACTURER
ratiopharm GmbH, Germany;
produced by Merkle GmbH, ul. Ludwig Merkle 3, 89143 Blaubeuren, Germany.

Representative office of the company:
123001 Moscow, Vspolny lane, 19/20, building 2

Ambrobene is an antitussive drug with mucolytic (promoting sputum thinning) action. Has a positive effect on the lungs in the prenatal period.

Pharmacological action of Ambrobene

The active ingredient of Ambrobene is ambroxol hydrochloride, a chemical compound that has a pronounced effect on the glandular cells of the bronchi and alveoli of the lungs. Reduces the viscosity of sputum (mucolytic effect) by stimulating its secretion with increased release of surfactant - a surfactant contained in the lungs and bronchi with the normalization of serous and mucous, that is, liquid and viscous components of sputum. It affects the mobility of the cilia of the ciliated epithelium lining the respiratory tract, accelerating the movement of sputum outward (secretomotor effect).

In the prenatal (antenatal) period, it has a stimulating effect on lung development, increasing the production and release of surfactant, while simultaneously preventing its breakdown. This effect is associated with the use of Ambrobene to prevent pulmonary failure in children born prematurely.

Release form and analogues

The drug Ambrobene is available in the following dosage forms:

Tablets – 30 mg of active ingredient each, in a package of 20 pcs.;
Capsules containing 75 mg ambroxol hydrochloride, 10 and 20 pcs. packaged;
Ambrobene solution for oral administration and inhalation, containing the active substance 7.5 mg per 1 ml, in bottles of 40 and 100 ml;
Solution for injection, also containing 7.5 mg of ambroxol per 1 ml of the drug, in ampoules of 2 ml, in a package of 5 pcs.;
Ambrobene syrup, containing 5 mg of active substance per 1 ml, in 100 ml bottles.

Analogs of Ambrobene with the same active ingredient in the composition are the following drugs: Lazolvan, Ambroxol, Ambrosan, Medovent, Ambrohexal, Ambrolan, Ambrosol, Deflegmin, Bronchorus, Bronkhoxol, Mucobron, Neo-bronchol, Suprima-kof, Fervex for cough, Flavamed, Halixol.

Indications for use of Ambrobene

In accordance with the instructions, Ambrobene is effective for respiratory diseases accompanied by the production of sputum with increased viscosity. These include:

Acute bronchitis;
Chronical bronchitis;
Bronchial asthma;
Chronic obstructive pulmonary disease;
Bronchiectasis.

This drug is also used in obstetric practice to stimulate the maturation of the lungs, if it is necessary to perform an artificial birth ahead of schedule or if there is a threat of spontaneous premature birth in the period 28-34 weeks of pregnancy. This use of Ambrobene is an effective prevention of respiratory distress syndrome, which often develops in premature infants due to the unpreparedness of the lungs to perform their functions.

Dosage and regimen of Ambrobene

According to the instructions, Ambrobene is indicated in the following dosages:

Adults and children over 12 years of age: 1 tablet 3 times a day for the first 3 days, then 1 tablet 2 times a day, or ½ tablet 3 times a day until the cough subsides;

Ambrobene in capsules is taken 1 capsule 1 time per day.

Parenteral: injection of 1 ampoule 2-3 times a day for adults, in severe condition the dosage may be doubled. For children, the dose for parenteral administration is calculated as 1.2-1.6 mg of ambroxol hydrochloride per 1 kg of body weight.

Ambrobene solution for oral administration and inhalation is taken according to the following scheme:

Adults, as well as children over 12 years old, 4 ml 3 times. per day for the first 3 days, then 4 ml 2 times. per day, or 2 ml 3 times. per day;

Up to 2 years, 1 ml 2 times. per day;

2-5 years 1 ml 3 r. per day;

5-12 years 2 ml 2-3 r. per day.

Ambrobene for inhalation is used as follows:

Adults, as well as children over 5 years old, 1-2 inhalations per day, 2 (children) -3 (adults) ml of solution;

Children under 5 years old – 1 inhalation per day, 2 ml of solution.

Ambrobene syrup:

For adults, as well as children over 12 years of age, 10 ml 3 times a day in the first 3 days of illness, then 10 ml 2 times a day or 5 ml 3 times a day;

up to 2 years, 2.5 ml 2 r. per day;

2-5 years 2.5 ml 3 rubles. per day;

5-12 years, 5 ml of Ambrobene syrup 2-3 r. per day.

Treatment of pulmonary insufficiency in the prenatal period is carried out according to the following scheme: 10 mg of ambroxol hydrochloride per 1 kg of body weight per day, divided into 3-4 parenteral administrations. The maximum permissible dosage in case of a serious condition of a child is 30 mg of ambroxol hydrochloride per 1 kg of body weight per day, which must also be divided into 3-4 administrations.

Contraindications to the use of Ambrobene

The use of Ambrobene is contraindicated in the following situations:

Individual intolerance to ambroxol hydrochloride;
Ulcerative diseases of the gastrointestinal tract;
1st trimester of pregnancy;
Breastfeeding period.

Undesirable effects

If the dosage is followed in accordance with the instructions, Ambrobene is usually well tolerated, and its use rarely leads to side effects. However, in clinical practice, the following side effects have been recorded with its use:

From the immune system: allergic reactions of delayed and immediate types (urticaria, exanthema, angioedema, anaphylactic shock);
From the respiratory tract – shortness of breath, a feeling of dryness in the respiratory tract, rhinorrhea;
From the urinary organs – dysuria;
From the nervous system – headache;
From the digestive tract - dyspeptic symptoms of varying intensity (nausea, vomiting, diarrhea, pain in the epigastric region);
From the cardiovascular system – decreased blood pressure;
Other – fever, chills, dry mouth.

special instructions

Ambrobene may interact with other medicinal substances, which should be taken into account in complex therapy. Pharmacologically incompatible with medications that have an alkaline reaction; their combined use is unacceptable due to possible neutralization (Ambrobene solution has an acidic reaction).

Do not use simultaneously with other antitussive drugs due to a decrease in the therapeutic effect.

The effect of using Ambrobene is enhanced by drinking plenty of fluids, so during therapy with this drug it is necessary to maintain a drinking regime with a high fluid content.

Ambrobene storage conditions and periods

Store in sealed packaging out of direct sunlight, in a place inaccessible to children at an air temperature not exceeding 25°C.

If these conditions are met, the shelf life of all forms of the drug is 5 years.

Ambrobene can be dispensed without a doctor's prescription.