Ibuklin 200 instructions for use. Ibuklin tablets: instructions, price, reviews and analogues

Drugs

Short description

Effects when used simultaneously with ibuclin

Anticoagulants (heparin, warfarin, lioton)

Drugs that inhibit the activity of the blood coagulation system and prevent the formation of blood clots.

Ibuklin may enhance the effect of these drugs. The effect of warfarin may be enhanced by long-term use of ibuclin and there may be a risk of bleeding.

Antihypertensive drugs

Various pharmacological drugs that are used to treat hypertension ( characterized by a persistent increase in blood pressure).

Ibuklin may reduce the effect of these drugs.

Cardiac glycosides(digoxin, corglycon)

Medicines that are used to treat acute and chronic heart failure.

Ibuklin can cause decompensation of heart failure and an increase in plasma levels of cardiac glycosides.

Diuretics(furosemide, indapamide, spironolactone, veroshpiron)

Pharmacological drugs that increase the excretion of water and salts from the body in the urine.

When using this drug, a decrease in the diuretic effect is observed. These drugs may also increase the risk of ibuclin nephrotoxicity.

Corticosteroids(prednisolone, hydrocortisone)

Body system

Side effects

The immune system

Nonspecific allergic reactions and anaphylaxis are very rare ( immediate reaction).

Lymphatic system and blood system

Rarely does hematopoiesis occur ( process of formation and development of blood cells) – leukopenia, anemia, neutropenia, thrombocytopenia and others.

Nervous system

Headache, dizziness, drowsiness, optic neuritis, aseptic meningitis ( inflammation of the membranes of the brain and spinal cord).

The cardiovascular system

Very rarely - edema, high blood pressure, heart failure, stomatitis, multiform reaction, which is manifested by the sudden appearance of swelling of the skin, subcutaneous tissue and muscles), anaphylactic shock. If the above conditions were previously observed while taking this drug or from the same group, then you should warn your doctor about this before he prescribes treatment.

How does an overdose of ibuclin manifest itself?

Price ( price) ibuklina in pharmacies in different cities of Russia

Do I need a doctor's prescription to buy ibuclin?

How to store ibuclin?

Shelf life of ibuklin

Pharmacotherapeutic group

Nonsteroidal anti-inflammatory and antirheumatic drugs. Propionic acid derivatives.
ATX code: M01AE51

Compound

Each tablet contains active ingredients: ibuprofen – 400 mg, paracetamol – 325 mg.
Excipients: microcrystalline cellulose, corn starch, glycerin, sodium starch glycolate, colloidal anhydrous silicon dioxide, purified talc, magnesium stearate, hypromellose (6 cps), macrogol (polyethylene glycol 6000), FCF orange yellow varnish (E 110), titanium dioxide (E171), sorbic acid, polysorbate 80, dimethicone.

Description

Film-coated tablets, orange or pale orange in color, possible spotty or marbled color inhomogeneity, capsule-shaped, with beveled edges, one side is smooth, the other is scored.

Pharmacological properties

Pharmacodynamics
Ibuprofen a nonsteroidal anti-inflammatory drug, a derivative of phenylpropionic acid, has anti-inflammatory, antipyretic and analgesic effects due to inhibition of the activity of COX, the main enzyme responsible for the metabolism of arachidonic acid, which is a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. The analgesic effect is due to both peripheral (directly, through a decrease in prostaglandin synthesis) and central mechanisms (inhibition of prostaglandin synthesis in the central and peripheral nervous system). Suppresses platelet aggregation.
Paracetamol- a non-narcotic analgesic, has an analgesic, antipyretic and weak anti-inflammatory effect by suppressing the activity of COX and reducing the production of prostaglandins; has a predominant effect on the thermoregulation center in the hypothalamus.
Pharmacokinetics
Ibuprofen after oral administration, it is quickly and almost completely absorbed from the gastrointestinal tract. The maximum concentration in the blood after taking film-coated tablets is determined after 1-2 hours. In synovial fluid, the maximum concentration is reached 3 hours after administration. Ibuprofen is metabolized in the liver (90%). It is excreted by the kidneys (80% of the administered dose) both unchanged (10%) and in the form of metabolites (70%). 20% is excreted as metabolites through the intestines. The half-life is about 2-3 hours.
Paracetamol quickly absorbed from the gastrointestinal tract, mainly in the small intestine; after a single dose, the maximum concentration in the blood is reached after 10-60 minutes, then gradually decreases. Paracetamol is well distributed in tissues and fluids, with the exception of adipose tissue and cerebrospinal fluid. Protein binding is less than 10%. Metabolized primarily in the liver by binding to glucuronide, sulfate and oxidation with the participation of liver oxidases and cytochrome P450. In adults, most of paracetamol is bound to glucuronic acid, in children - to sulfuric acid. These conjugated metabolites do not have metabolic activity and do not bind to plasma proteins. Also, in case of overdose, accumulation of a hydroxylated metabolite with a toxic effect, N-acetyl-p-benzoquinone imine, may occur, which is formed in the liver and kidneys under the influence of mixed oxidases and under normal conditions is detoxified by binding to glutathione.
The half-life is 1-3 hours and may increase with cirrhosis of the liver. The renal clearance of paracetamol is 5%. It is excreted unchanged (about 5%) and in the form of glucuronide and sulfate conjugates.

Indications for use

Temporary relief of mild to moderate pain caused by migraine, headache, back pain, toothache, menstrual pain, rheumatic and muscle pain, pain in uncomplicated and/or mild forms of arthritis, sore throat, pain syndromes in inflammatory diseases of the ENT- organs.
This drug is recommended for use in cases where the analgesic effect of ibuprofen or paracetamol monotherapy is insufficient.

Directions for use and dosage regimen

Adults Ibuklin are usually prescribed 1 tablet 2-3 times a day after meals. The maximum daily dose is 3 tablets, the interval between doses should not be less than 8 hours. The drug should not be taken for more than 5 days as a pain reliever. If symptoms persist for more than 3 days or the condition worsens, you should consult a doctor. In order to minimize the risk of adverse reactions, ibuprofen should be taken in the minimum effective dose and for the shortest period necessary to achieve a clinical effect.

Side effects

Clinical trial results suggest a possible association between ibuprofen, especially at high doses (≥ 2400 mg/day), and a small increased risk of arterial thrombotic events (eg, myocardial infarction and stroke).
The following adverse reactions are classified by organ, system and frequency of occurrence, with the most common listed first. Classification of the frequency of occurrence of adverse reactions: very often (≥ 1/10), often (> 1/100 and ≤ 1/10), infrequently (> 1/1000 and ≤ 1/100), rarely (> 1/10000 and ≤ 1 /1000), very rare (≤ 1/10000, including isolated messages). For each frequency group, adverse reactions are listed in order of increasing severity.
Blood system and lymphatic system: very rarely - disorder of hematopoiesis (agranulocytosis,
anemia, aplastic anemia, hemolytic anemia, leukopenia, neutropenia, pancytopenia, thrombocytopenia).
The immune system: very rarely - hypersensitivity reactions (nonspecific allergic reactions and anaphylaxis).
Mental disorders: very rarely - confusion, depression, hallucinations.
Nervous system: infrequently – headache and dizziness; very rarely - paresthesia, optic neuritis, drowsiness, aseptic meningitis.
Organ of vision: very rarely - visual impairment.
Hearing organ and vestibular apparatus: very rarely - tinnitus and dizziness.
The cardiovascular system: very rarely - edema, hypertension, heart failure.
Respiratory system and chest organs: very rarely - asthma, worsening asthma, bronchospasm, dyspnea.
Digestive system: often – abdominal pain, diarrhea, dyspepsia, nausea, stomach discomfort, vomiting; uncommon – flatulence, constipation, stomach ulcer, perforation or gastrointestinal bleeding with symptoms of melena, bloody vomiting, sometimes fatal, more often in the elderly, ulcerative stomatitis, exacerbation of ulcerative colitis and Crohn’s disease, gastritis, pancreatitis.
Hepatobiliary system: very rarely - liver dysfunction, hepatitis, jaundice, acute liver failure, liver necrosis, liver damage (in case of paracetamol overdose).
Skin and subcutaneous fat: uncommon - rash of various types, including itching and urticaria, Quincke's edema and facial swelling; very rarely - hyperhidrosis, purpura, photosensitivity, exfoliative dermatitis, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis.
Kidneys and urinary system: very rarely - nephrotoxicity in various forms, including interstitial nephritis, nephrotic syndrome, acute and chronic renal failure.
General violations: very rarely - fatigue and malaise.
Research: often - increased ALT and gamma-glutamyltransferase, abnormal liver function tests, increased creatinine and urea; infrequently - increased AST, alkaline phosphatase and CPK, decreased hemoglobin, increased platelet count.
The first signs of hematopoiesis disorder: fever, sore throat, superficial mouth ulcers, flu-like symptoms, exhaustion, unexplained bleeding and bruising, nosebleeds.
Hypersensitivity reactions were manifested by swelling of the face, tongue and larynx, dyspnea, tachycardia, hypotension, Quincke's edema, and anaphylactic shock.
Isolated cases of aseptic meningitis have been reported in patients with autoimmune disorders (such as systemic lupus erythematosus and systemic connective tissue diseases) during treatment with ibuprofen, accompanied by symptoms: stiff neck, headache, nausea, vomiting, fever or confusion.

Contraindications

− increased individual sensitivity to the components of the drug;
- a history of hypersensitivity reactions (bronchospasm, urticaria, asthma, rhinitis, rash and other allergic symptoms) when using acetylsalicylic acid or other NSAIDs;
− acute stomach or intestinal ulcer; gastrointestinal bleeding or perforation, as well as patients with a history of these diseases, including those associated with taking non-steroidal anti-inflammatory drugs (NSAIDs);
− diseases of the blood system, defects of coagulation hemostasis;
- damage to the optic nerve;
− impaired renal function when the glomerular filtration rate decreases to less than 30 ml/min;
− liver or kidney diseases;
− severe heart failure (NYHA IV);
- combined use with other NSAIDs, including COX-2 inhibitors and acetylsalicylic acid more than 75 mg/day - increases the risk of adverse reactions;
− combined use with paracetamol-containing drugs – increases the risk of adverse reactions;
− genetically determined absence of glucose-6-phosphate dehydrogenase;
− pregnancy;
− lactation;
− age up to 18 years.

Overdose

Paracetamol
Taking 10 g of paracetamol or more may cause liver damage in adults. Ingestion of 5 g of paracetamol or more may cause liver damage if the patient has one or more risk factors:
long-term treatment with carbamazepine, phenobarbital, phenytoin, primidone, rifampicin, St. John's wort or other drugs that induce liver enzymes;
regular consumption of alcohol in excess of safe doses;
glutathione deficiency, which can be observed in eating disorders;
cystic fibrosis, HIV infection, fasting, cachexia.
Symptoms: Symptoms of paracetamol overdose in the first 24 hours include pallor, nausea, vomiting, anorexia and abdominal pain. Liver damage may become apparent 12 to 48 hours after ingestion when liver function tests change. Impaired glucose metabolism and metabolic acidosis may develop. In severe poisoning, liver failure can progress to encephalopathy, bleeding, hypoglycemia, cerebral edema and lead to death. Acute renal failure with acute tubular necrosis, manifested by low back pain, hematuria and proteinuria, can develop even in the absence of severe liver damage. Heart rhythm disturbances and the development of pancreatitis have also been recorded.
Treatment: Paracetamol overdose requires immediate medical attention even if there are no symptoms in the early period. An overdose may only result in nausea or vomiting and may not be consistent with the severity of the poisoning or the risk of organ damage. When treating, it is necessary to be guided by local established principles of therapy. It is necessary to take activated carbon within 1 hour after taking paracetamol orally. Plasma concentrations of paracetamol should be assessed 4 hours or later after dosing (earlier concentration determinations are unreliable). Treatment with N-acetylcysteine ​​can be used within 24 hours of taking paracetamol, however, the maximum protective effect occurs when taking N-acetylcysteine ​​within 8 hours of taking paracetamol. The effectiveness of the antidote action decreases sharply after this time. In the absence of vomiting, oral methionine may be used as an alternative if acetylcysteine ​​cannot be administered. Management of patients with severe liver damage more than 24 hours after taking paracetamol should be in accordance with local practice.
Ibuprofen
Symptoms. Most patients who have taken a clinically significant amount of NSAIDs develop nausea, vomiting, epigastric pain, and less commonly, diarrhea. You may also experience tinnitus, headache, and gastrointestinal bleeding. In more severe cases, central nervous system toxicity may develop, manifested by drowsiness, sometimes agitation and confusion or coma. Sometimes seizures develop. In severe cases, metabolic acidosis and prolongation of prothrombin time/INR may develop, probably due to the effect on circulating coagulation factors. Acute kidney failure and liver damage may occur, especially if dehydration is present. Patients suffering from bronchial asthma may develop an exacerbation.
Treatment. Treatment should be symptomatic and supportive and include airway management and monitoring of cardiac and vital signs until the condition has stabilized. It is recommended that activated charcoal be administered orally within 1 hour of taking a potentially toxic dose.

Precautionary measures

Elderly patients: the risk of developing adverse reactions, especially from the gastrointestinal tract (bleeding, perforation) in this category of patients is higher, and therefore caution is recommended when using the drug.
Respiratory diseases: NSAIDs may cause bronchospasm in patients suffering from bronchial asthma or allergic diseases.
The cardiovascular system: NSAIDs may cause fluid retention and edema, which may worsen the condition of patients with hypertension and/or heart failure. Clinical trial results suggest a possible association between ibuprofen, especially at high doses (≥ 2400 mg/day), with a small increased risk of arterial thrombotic events (eg, myocardial infarction and stroke). Epidemiological studies do not suggest an association between low-dose ibuprofen (≤ 1200 mg/day) and an increased risk of arterial thrombotic events. In patients with uncontrolled hypertension, NYHA class II-III congestive heart failure, established coronary artery disease, peripheral arterial disease and/or cerebrovascular disease, ibuprofen should be prescribed only after a careful benefit-risk assessment, and high doses of ibuprofen should be avoided. (2400 mg/day). Before initiating long-term ibuprofen therapy, especially at high doses (≥ 2400 mg/day), in patients with risk factors for cardiovascular complications (eg, hypertension, hyperlipidemia, diabetes mellitus, smoking), a careful benefit-risk assessment should be performed.
Gastrointestinal tract: NSAIDs can cause bleeding, ulcers and perforation of the gastrointestinal tract, including in patients who have no previous history of gastrointestinal diseases. The risk of these complications is higher in patients with a complicated medical history, when using high doses of NSAIDs, and in elderly patients, and therefore in this group it is recommended to start therapy with the minimum recommended dose. The use of drugs such as misoprostol or proton pump inhibitors should also be considered in this category of patients, as well as in individuals requiring concomitant use of low doses of salicylic acid or other drugs that may increase the risk of gastrointestinal side effects (corticosteroids, anticoagulants, regurgitation inhibitors). serotonin uptake, etc.). Patients with a history of episodes of gastrointestinal bleeding should be informed of the need to report to their physician the occurrence of any unusual gastrointestinal symptoms, especially during the initial phase of therapy. If symptoms of gastrointestinal ulcers or bleeding occur, the drug should be stopped immediately. NSAIDs should be used with caution in patients with a history of gastrointestinal diseases (ulcerative colitis, Crohn's disease) due to the risk of worsening the condition.
Systemic diseases: In patients with systemic lupus erythematosus and other connective tissue diseases, NSAIDs may increase the risk of developing aseptic meningitis.
Dermatological disorders: very rarely, when using NSAIDs, severe skin reactions were observed, including fatal ones (exfoliative dermatitis, Steven-Johnson syndrome, toxic epidermal necrolysis). The risk of these disorders occurring is higher during the first month of taking NSAIDs. In this regard, you should stop taking the drug if any rashes on the skin and mucous membranes occur, as well as any other signs of hypersensitivity.
Renal dysfunction: the risk of complications is higher in patients in whom the production of prostaglandins plays a compensatory role to maintain renal blood flow (state of dehydration, impaired liver and kidney function, heart failure, severe atherosclerosis, taking diuretics, ACE inhibitors, elderly patients). In this regard, when prescribing the drug to patients at risk, the following precautions are recommended:
monitoring of liver and kidney functions when prescribing the drug to elderly patients, patients with arterial hypertension and diabetes mellitus during the first week of use when prescribing the drug for more than 1 week.
control of serum creatinine 48-72 hours after starting the drug in patients with chronic heart failure and chronic renal failure with a glomerular filtration rate of less than 60 ml/min.
Also, the drug should be used with caution in patients with impaired liver or kidney function, immediately after surgery, with a history of allergic reactions associated with taking NSAIDs, polyps of the nasal mucosa. With long-term (more than 5 days) use of the drug, monitoring of peripheral blood and the functional state of the liver and kidneys is necessary. If signs of impaired renal function (lower back pain, decreased daily urine volume, swelling) or liver (pain in the hypochondrium, jaundice, change in urine color) occur, you should immediately stop taking the drug and consult your doctor.
To avoid possible hepatotoxic effects of the drug, it is recommended to refrain from drinking alcohol during treatment.

Pregnancy and lactation

During pregnancy and lactation, the use of the drug is not recommended. If it is necessary to take it during lactation, it is necessary to decide on the transfer to artificial feeding. The drug may affect female fertility, and therefore its use is not recommended for patients planning to become pregnant. In women experiencing problems conceiving, the drug should be discontinued.

Impact on the ability to drive vehicles and other mechanisms

Drug interactions

This medicine (like all medicines containing paracetamol) is contraindicated in combination with other medicines containing paracetamol due to the increased risk of serious side effects (see Side Effects section).
This drug (like any other drugs containing ibuprofen and NSAIDs) is contraindicated in combination with:
acetylsalicylic acid: simultaneous use of ibuprofen and acetylsalicylic acid is not recommended due to a possible increase in the development of adverse events. Laboratory studies suggest that ibuprofen, when used concomitantly with low doses of acetylsalicylic acid, may competitively inhibit platelet aggregation. Although the admissibility of extrapolation of these data to clinical practice remains uncertain, the possible effect of regular long-term use of ibuprofen on reducing the cardioprotective effect of low doses of acetylsalicylic acid cannot be excluded. The effect of occasional use of ibuprofen on the cardioprotective properties of acetylsalicylic acid seems unlikely.
other NSAIDs, including selective cyclooxygenase type 2 inhibitors, because there may be an increased risk of side effects (see section "Side Effects").
This medicine (like any other medicines containing paracetamol) should be used with caution in combination with:
chloramphenicol: plasma concentrations of chloramphenicol increase.
cholestyramine: the rate of absorption of paracetamol decreases. If maximum pain relief is required, cholestyramine should be taken no earlier than an hour after taking Ibuklin.
metoclopramide and domperidone: absorption of paracetamol increases. It is necessary to avoid taking these drugs together.
warfarin: the effect of warfarin and other coumarins may be enhanced by long-term regular use of paracetamol with an increased risk of bleeding. A single application does not have a significant effect.
This drug (like any other drugs containing ibuprofen and NSAIDs) should be used with caution in combination with:
Anticoagulants: NSAIDs may enhance the effect of anticoagulants such as warfarin.
Antihypertensives: NSAIDs may reduce the effects of these drugs.
antiplatelet agents and selective serotonin reuptake inhibitors (SSRIs): the risk of gastrointestinal bleeding increases.
Acetylsalicylic acid: Experimental evidence suggests that ibuprofen may inhibit the effect of low doses of acetylsalicylic acid on platelet aggregation when administered concomitantly. However, data limitations and the uncertainty of extrapolating study results to clinical practice make it impossible to draw conclusions for the regular use of ibuprofen. The clinical significance of this effect for a single dose of the drug is considered unlikely.
cardiac glycosides: NSAIDs can cause decompensation of heart failure, a decrease in GFR and an increase in plasma levels of cardiac glycosides.
cyclosporine: increased risk of nephrotoxicity.
corticosteroids: increased risk of gastrointestinal bleeding or ulcers.
diuretics: the diuretic effect is reduced. Diuretics may increase the risk of NSAID nephrotoxicity.
lithium: lithium elimination decreases.
methotrexate: the elimination of methotrexate is reduced.
Mifepristone: NSAIDs should not be used within 8-12 days of taking mifepristone as NSAIDs may reduce the effect of mifepristone.
Quinolone antibiotics: Animal studies have shown that NSAIDs may increase the risk of seizures associated with the use of quinolone antibiotics. Patients taking NSAIDs and quinolones may have an increased risk of developing seizures.
tacrolimus: possible increased risk of nephrotoxicity.
zidovudine: increased risk of hematological toxicity. Cases of increased risk of hemarthrosis and hematoma have been reported in HIV (+) hemophilia patients receiving concomitant treatment with zidovudine and ibuprofen.
The risk of developing adverse reactions from the kidneys increases when ibuprofen is co-administered with drugs that affect the renin-angiotensin-aldosterone system
Manufactured
Dr. Reddy's Laboratories Ltd Village Col, Baddi, Nalagarh Road, Solan District, Himachal Pradesh, India.
Packed
Open Joint Stock Company "Borisov Medical Preparations Plant"
Republic of Belarus, Borisov, st. Chapaeva 64.

Ibuklin is an antipyretic, analgesic and anti-inflammatory drug. Instructions for use recommend taking tablets (100 mg + 125 mg) and (400 mg + 325 mg) for adults and the children's form Junior to eliminate febrile syndrome and high temperature for colds and other infectious and inflammatory ailments, for dental, headache, joint and muscle pain.

Release form and composition

The drug is produced for children and adults.

Ibuklin for children is produced in the form of round, pink, interspersed, dispersible tablets with a fruity-mint odor. Each tablet contains 100 mg ibuprofen and 125 mg paracetamol.

Ibuklin tablets for adults (the instructions for use provide this information) are produced in the form of capsule-shaped orange film-coated tablets. Each tablet contains 400 mg ibuprofen and 325 mg paracetamol.

pharmachologic effect

The effect of the drug Ibuklin is due to the pharmacological properties of its active components. Paracetamol and ibuprofen stop the development of inflammatory processes in the body, providing it with a pronounced analgesic, antipyretic and anti-inflammatory effect.

According to the instructions, the use of Ibuklin leads to a decrease in pain in the joints during movement and at rest, a decrease in their swelling and an increase in range of motion. This drug has a longer lasting effect than its active substances individually.

What does Ibuklin help with?

Indications for the use of the drug Ibuklin include increased body temperature (febrile syndrome) with colds and other infectious and inflammatory diseases, as well as pain of mild or moderate intensity of various etiologies:

• headache;
• toothache;
• for diseases of periarticular tissues (tenosynovitis, bursitis);
• post-traumatic pain syndromes (bruises, sprains, dislocations, fractures, soft tissue bruises);
• for degenerative diseases of the musculoskeletal system (deforming osteoarthritis, osteochondrosis);
• lumbago, sciatica, neuralgia, myalgia;
• for inflammatory diseases of the musculoskeletal system (rheumatoid arthritis, psoriatic, juvenile and chronic arthritis, ankylosing spondylitis, gouty arthritis).

Instructions for use

Ibuklin for adults

The tablets are taken before meals, or 2-3 hours after meals. The tablets do not need to be chewed; wash them down with plenty of water.

Adults need to take one Ibuklin tablet three times a day. Three tablets is the maximum allowable dose of the drug. There should be at least 4 hours between taking pills. For older people and for those who suffer from impaired renal and liver function, the interval between taking tablets should be at least 8 hours.

Children over 12 years old and who weigh more than 40 kg take 1 tablet 2 times a day.

Treatment with Ibuklin to reduce fever can last no more than three days. The drug can be used as a pain reliever for no more than five days. If you need to continue therapy, you should first consult your doctor.

For children

The instructions for using children's Ibuklin are as follows: one tablet of the drug Junior is dissolved in one teaspoon of warm water.

The dosage of Ibuklin Junior for children is made depending on their body weight:

• with a weight of 11-15 kg – 1 tablet 1 time every 8 hours, 3 times a day;
• 16-21 kg – 1 tablet 1 time in 6 hours, 4 times a day;
• 22-40 kg – 2 tablets 1 time every 8 hours, 3 times a day;
• over 40 kg the minimum dose for adults is taken.

Contraindications

Ibuklin instructions for use prohibit:

• damage to the optic nerve;
• diseases of the blood system;
• confirmed hyperkalemia;
• children under 12 years of age (tablets for adults);
• children under 3 years of age (subject to the use of a special children's form Ibuklin Junior);
• III trimester of pregnancy, lactation period;
• period after coronary artery bypass surgery;
• increased individual sensitivity to the components of the drug (including other NSAIDs);
• peptic ulcer of the stomach and duodenum in the acute phase;
• gastrointestinal bleeding;
• inflammatory bowel diseases;
• severe renal failure (creatinine clearance less than 30 ml/min);
• active gastrointestinal bleeding;
• genetic absence of glucose-6-phosphate dehydrogenase;
• complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (including a history);
• progressive kidney disease, severe liver failure or active liver disease.

Side effects

The medicine can cause the following negative reactions in the body:

• hives;
• skin rash;
• dyspeptic symptoms;
• thrombocytopenia, leukopenia, pancytopenia, neutropenia, agranulocytosis;

Children, pregnancy and breastfeeding

In the first and second trimesters of pregnancy, use is possible only as prescribed by a doctor in cases where the potential benefit outweighs the possible risk to the mother and the potential risk to the fetus. The use of the drug in the third trimester of pregnancy is contraindicated.

If it is necessary to use the drug during lactation, breastfeeding should be stopped.

Adult tablets are not prescribed for the treatment of children under 12 years of age. Ibuklin Junior is not prescribed to children under three years of age.

special instructions

The combined use of the drug with other drugs containing paracetamol should be avoided. When taking Ibuklin for more than 5-7 days, the functional state of the liver and peripheral blood parameters should be monitored.

It is recommended to avoid co-administration with other NSAIDs. To avoid damaging effects on the liver, you should not drink alcohol while taking Ibuklin. When prescribing indirect anticoagulants simultaneously, it is necessary to monitor the parameters of the blood coagulation system.

Drug interactions

The use of Ibuklin together with ethanol, corticotropin and glucocorticosteroids increases the risk of developing erosive and ulcerative lesions of the gastrointestinal tract.

Ibuprofen increases the effect of insulin, colchicine, thrombolytic agents, oral hypoglycemic drugs, antiplatelet agents, direct and indirect anticoagulants. Caffeine increases the analgesic effect of ibuprofen, and cholestyramine and antacids reduce its absorption in the body.

The use of the drug weakens the effectiveness of diuretics and antihypertensive drugs, but at the same time increases the concentration in the blood of digoxin, methotrexate and lithium preparations.

Analogues of the drug Ibuklin

Analogues are determined by structure:

1. Khairumath.
2. Next
3. Brustan.

Vacation conditions and price

The average price of Ibuklin (tablets for adults No. 10) in Moscow is 109 rubles. In Kyiv you can buy medicine for 160 hryvnia. It is difficult to find the drug in Kazakhstan. In Minsk, pharmacies offer Ibuklin (No. 20) for 6-7 bel. rubles Dispensed from pharmacies with a prescription.

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