Is it possible to nimesil. What is nimesil, in what cases and how to take it correctly

Nimesil powder is an antipyretic, anti-inflammatory drug. As for dentistry specifically, the powder used for stomatitis, periodontitis, toothache, gum inflammation, for infection and for general prevention of the oral cavity.

Nimesil powder - brief description, composition, release form

Nimesil powder was developed by American pharmacists. It does not have such a large number of analogues - only two. May have allergic reactions and other side effects. It can be produced without a doctor's prescription, but for severe indications - only with a prescription. The company that produces Nimesil is Burling Hemi. Nimesil contains one active substance: nimesulide in a mass of 100 g.

And also excipients:

• Ketomacrogol
• Sucrose
• Maltodextrin
• Lemon acid
• Orange flavor

The active substance is present in amounts greater than 1%, auxiliary substances less than 1%.

Available in a cardboard box in a laminated bag containing granules for preparing the procedure. There are 30 bags of granules in a cardboard box.

Should be stored in a dark, cool place, where the temperature does not exceed 20 degrees Celsius. Best stored in the refrigerator. Shelf life: 2 years.

The appearance of the powder in the capsule is has a yellow color with an orange smell.

Pharmacological properties

Pharmacological properties are: antipyretic, anti-inflammatory effect. Nimesil acts quickly, thanks to its active substance nimesulide, which plays the role of an antipyretic substance. The effect of the drug is average, about 6 hours.

Indications for use in dentistry

In general, nimesil is used for various indications, but specifically in dentistry it is used for:

• Toothache (reduces pain).
• Mouth infections
• Inflammation of the sockets after tooth extraction
• Gum inflammation
• Periodontitis
• Stomatitis

The drug can be taken both for a long time and for a short time, in case of urgent need. Usually, with long-term use, it is taken for two weeks, with short-term use, 2-3 days.

Contraindications

The drug should not be taken with the following contraindications:

• Pregnancy (it is unknown how the body will react to the drug).
• Lactation period (during lactation it is prohibited to consume any medications)
• Physical intolerance to any component of nimesil (nimesulide, excipients)
• Bleeding from the gastrointestinal tract
• Stone disease
• Diabetes
• Hypersensitivity to a substance in the drug
• Heart failure
• Heartburn (the action of the powder will only worsen heartburn)
• Vomit
• Sharp pain in the abdomen
• Contraindicated in children under 14 years of age.

Instructions for use

The drug is used only by adults; it is strictly prohibited for children. The usual dose is 200 mg per day. Should be used after meals twice a day: morning and evening. In the morning - 100 mg, in the evening - 100 mg.

In order to make the solution, you need to take one package out of the box, take out the granule and dissolve it in warm boiled water. For severe indications, the dose can be increased. For use by older people, the dose should be changed depending on the indication. Also, in case of severe indications, it is necessary for the doctor to strictly control the dosage and the use of the drug itself.

Interactions with other medications

If, in addition to Nimesil, you consume drugs to improve blood clotting, the effect of Nimesil will be high. If Nimesil is consumed together with lithium preparations, the concentration of lithium in the blood will be increased.

In addition, Nimesil easily enters into preparations with a protein composition.

While consuming the drug you need to strictly monitor the doses, otherwise side effects may occur. Use the drug with caution together with diuretics. You should not combine the powder with drugs to lower blood pressure or with drugs of any cardiac nature.

Side effects

Nimesil has quite a lot of side effects, this is again related to nimesulide and its action:

• Dizziness
• Nausea
• Vomit
• Drowsiness
• Hypertension
• Tachycardia (rare)
• Hemorrhage
• Diarrhea
• Visual impairment (rare)
• Dyspnea
• Hepatitis (rare)
• Jaundice (rare)
• Hematuria (rare)
• Kidney failure (rare)
• Anemia (rare)
• Purpura (rare)
• Constipation (rare)
• Heavy sweating

Price for the drug and analogues

The average price of Nimesla in Russia for 30 sachets of 100 mg granules is from 600 to 900 rubles. In online pharmacies from 500 to 850 rubles.

Nimesil's analogs:

• Aponil. Aponil has the same active substance as nimesil - nimesulide. The drug itself is available in small tablets of 100 mg. There are usually 20 tablets in a cardboard box. As for the dose, then for an adult 100 mg per day is enough, children under 12 years old, should be calculated: 1.5 mg per 1 kg of weight. The average price of Aponil for 20 tablets of 100 mg in Russia is from 150 to 370 rubles, for 30 tablets of 100 mg from 220 to 400 rubles. Application of Aponil pregnant women are strictly prohibited. Available without a doctor's prescription.
• Nise. Nise has the same active substance as nimesil - nimesulide. Nise is available in 100 mg tablets. There are usually 20 tablets in a cardboard box. For adults you need to take 100 mg per day, twice a day. For children should be taken twice a day, calculating 3 mg per 1 kg of weight. Also available in gel, which is used externally. To apply the gel, you need to wash and dry the skin, then apply to the affected area of ​​the body. Average price of Nise in tablets from 200 to 350 rubles, in gel from 150 to 250 rubles. Nise consumption tablets are strictly prohibited for pregnant women. Available without a doctor's prescription. Here you can read in detail.

Nimesil - instructions for use, price, reviews and analogues - we will consider all this in this article. Nimesil NIMESIL® (powder) is a drug that is an analgesic and antipyretic drug with a pronounced anti-inflammatory effect. Nimesil is praised by many patients who have experienced dental, headache, menstrual pain, as well as pain after operations and injuries.

Nimesil® - read the instructions before use

Nimesil instructions indicate a wide range of its use and clinical effects. Are you interested in the question of what Nimesil helps with? The powder effectively fights fever, rheumatism, it is prescribed for neuralgia, bursitis, and can simultaneously eliminate pain syndromes accompanying injuries to soft tissues and the musculoskeletal system.

The balanced composition of the drug allows it to be used both for long-term therapy and for a course of symptomatic treatment or single use to relieve severe pain. The price of Nimesil depends on the manufacturer and type of packaging.

Release form and composition

The basis of the drug is nimesulide. As auxiliary components, the drug is supplemented with macrogol scetostearyl ether, maltodextrin, sucrose, citric acid, and citrus flavoring.

Nimesil in dosage form is a granulate - a soluble powdery structure of a light yellow hue, from which a suspension is prepared immediately before ingestion. The granulate is packaged in special three-layer laminated paper bags of 2 grams (dosage for a single dose).

Nimesil - indications for use

Nimesil is a drug that is used in the symptomatic treatment of joint and muscle pain. The main task that Nimesil performs is to stop the inflammatory process, eliminate pain, and reduce swelling at the time of use. Taking the drug Nimesil is indicated in the symptomatic treatment of pain caused by osteochondrosis.

The drug Nimesil is also used to relieve acute dorsal, traumatic, dentinal pain. The drug Nimesil effectively acts in pain syndrome, to relieve pain caused by the inflammatory process. The drug is actively used in the postoperative period.

The anti-inflammatory, decongestant property of Nimesil minimizes or completely suppresses inflammatory processes in the upper respiratory tract. The property of the drug Nimesil to rapidly relieve pain is most often used for pain of a paroxysmal nature, regardless of its origin.

How to dilute Nimesil powder

The medicine Nimesil is granules for the preparation of an oral suspension in the form of a light yellow powder with the smell of orange - 2 grams of Nimesil in a paper bag; 9, 30 or 15 sachets in a cardboard box.

How to take medicine to make the disease go away? After administration, it is well absorbed from the intestines, reaching its highest concentration in the blood after 2-3 hours. Reaction with plasma proteins is 97.5%. The half-life is 4-5 hours. Quickly penetrates histohematic barriers.

How to drink Nimesil if the disease takes you by surprise? The drug in powder (granules) is placed in a glass and diluted in approximately 100 ml. water. The prepared solution cannot be stored; it must be taken as soon as possible. There is a common question about what water to dissolve the powder in. The instructions recommend dissolving the medicine in warm, boiled water.

Directions for use and doses

Nimesil is taken orally, 1 sachet (100 mg 2 g of nimesulide) twice a day. The anti-inflammatory drug is recommended to be taken after meals. The contents of the sachet are poured into a glass and dissolved in approximately 100 ml. water. The prepared solution cannot be stored.

• Nimesil® is used only for the treatment of patients over 12 years of age;
• Adolescents (12 to 18 years): Based on the pharmacokinetic profile and pharmacodynamic characteristics of nimesulide, there is no need for dose adjustment in adolescents;
• Patients with impaired renal function: based on pharmacokinetic data, there is no need for dose adjustment in patients with mild to moderate forms of renal failure (creatinine clearance 30-80 ml/min);
• Elderly patients: when treating elderly patients, the need to adjust the daily dose is determined by the doctor based on the possibility of interaction with other drugs;
• The maximum duration of treatment with nimesulide is 15 days;
• To reduce the risk of unwanted side effects, the minimum effective dose should be used for the shortest possible course. Now you know how to take Nimesil

Compatibility and side effects

From the hematopoietic system: rarely - anemia, eosinophilia, hemorrhagic syndrome; very rarely - thrombocytopenia, pacytopenia, thrombocytopenic purpura.

Allergic reactions: uncommon - itching, rash, increased sweating; rarely - hypersensitivity reactions, erythema, dermatitis; very rarely - anaphylactoid reactions, urticaria, angioedema, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome).

From the side of the central nervous system: infrequently - dizziness; rarely - a feeling of fear, nervousness, nightmares; very rarely - headache, drowsiness, encephalopathy (Reye's syndrome).

From the side of the organ of vision: rarely - blurred vision.

From the cardiovascular system: uncommon - arterial hypertension, tachycardia, lability of blood pressure, hot flashes.

From the respiratory system: infrequently - shortness of breath; very rarely - exacerbation of bronchial asthma, bronchospasm.

From the digestive system: often - diarrhea, nausea, vomiting; infrequently - constipation, flatulence, gastritis; very rarely - abdominal pain, dyspepsia, stomatitis, tarry stools, gastrointestinal bleeding, ulcer and/or perforation of the stomach or duodenum; very rarely - hepatitis, fulminant hepatitis, jaundice, cholestasis, increased activity of liver enzymes.

From the urinary system: rarely - dysuria, hematuria, urinary retention; very rarely - renal failure, oliguria, interstitial nephritis.

General violations: rarely - malaise, asthenia; very rarely - hypothermia.

Others: rarely - hyperkalemia.

The abstract for Nimesil recommends using the drug with caution if severe forms of type 2 diabetes mellitus or arterial hypertension are present; ischemic disease, heart failure, dyslipidemia, cerebrovascular diseases, peripheral arterial diseases, old age;

peptic ulcer in the past, infections associated with Helicobacter pylori; long-term previous use of non-steroidal anti-inflammatory drugs; decompensated somatic diseases; with smoking and concomitant treatment with anticoagulants, oral glucocorticosteroids, antiplatelet agents, selective serotonin reuptake blockers.

Nimesil analogs that are cheaper than the drug

Modern pharmacies offer many analogues of this drug, and based on numerous recommendations, the effect of similar substances is not much different from the effect of using the main drug. The cost of Nimesil is from 30 rubles per 1 sachet, and varies depending on their quantity in the package. Analogs can be sold cheaper in both tablets and powder form.

• Nise– an effective pain reliever used for a wide range of phenomena, the cost is from 200 rubles per package;
• Nimesulide– costing from 70 rubles, this medicine is not inferior to the main substance in question and is much more profitable;
• Nemulex– the cost of this drug in the Russian Federation starts from 180 rubles, and the effect of the drug is not inferior to its analogues.

These medications contain the same amount of active ingredient. In addition, you can find other cheap drugs.

• Aponil– is related to non-steroidal drugs and has a pronounced anti-inflammatory effect, therefore it can be taken to relieve many processes in the area of ​​external and internal organs;
• Mesulid– belongs to the sulfonanilide class and has a pronounced effect in the fight against numerous diseases;
• Nimulid– the medicine is produced in several forms and is much cheaper than the drug in question. The price starts from 100 rubles per package;
• Prolide– the product is available in the form of quick-acting tablets. The advantage is a more affordable price and fewer negative side effects.

The action of many of the substances presented is similar to similar drugs, so if you have the opportunity to choose a more inexpensive option, you have the right to do so. However, do not forget about the consequences of self-medication, so it is best to consult with your doctor. The abstract for Nimesil is supplemented with recommendations from patients.

The active ingredient of Nimesil is nimesulide, which has a powerful systemic effect. Effective in the treatment of inflammatory febrile conditions, infectious and rheumatic processes, severe pain syndrome of various etiologies.

It is superior in action to popular drugs from the NSAID group (ibuprofen, diclofenac), working directly at the site of inflammation, but at the same time has a wide range of contraindications and side effects. It should be understood that, despite its high effectiveness, Nimesil is intended for symptomatic therapy, acting at the time of use and without affecting the etiological cause of the disease. Pharmgroup: NSAIDs - Non-steroidal anti-inflammatory drugs.

For whom the drug is contraindicated

• A combination of bronchial asthma, polyposis of the paranasal sinuses or nose with a recurrent course and a history of intolerance to NSAIDs;
• Confirmed hyperkalemia;
• History of cerebrovascular and other bleeding;
• Simultaneous treatment with other drugs that have a hepatotoxic effect (especially from the NSAID group);
• Children under 12 years old;
• Severe bleeding disorder;
• History of hyperergic reactions of the body: rhinitis, urticaria, bronchospasm, laryngospasm associated with taking any drug from the NSAID group, including nimesulide;
• Liver failure;
• Drug addiction, alcoholism;
• Recovery period after coronary artery bypass surgery;
• Severe heart failure;
• Inflammatory processes in the intestines in the acute phase (Crohn's syndrome, nonspecific ulcerative colitis);
• History of ulcer with bleeding or perforation;
• Liver disease in the acute phase;
• History of hepatotoxic reactions of the body to nimesulide;
• Hypersensitivity to the active base (nimesulide) or an auxiliary component of the drug;
• Severe renal failure;
• Pregnancy, lactation;
• Exacerbation of a stomach or duodenal ulcer;
• Diseases accompanied by bleeding;
• Fever that accompanies colds and acute respiratory viral infections.

Nimesil price

The price of Nimesil powder (30 sachets) reaches 900 rubles. For comparison, the price for 1 sachet of Nimesil is 25-32 rubles.

How much does the analogue of Nimesil Nise cost? The cost of this drug in the form of a 100 mg tablet. No. 20 is 175-215 rubles. Dispersible tablets differ from regular tablets in that they do not require swallowing. They are able to dissolve directly in the oral cavity. In addition, they can be placed in water, then taken as a solution in the form of a suspension. And this is the main advantage of a dispersed tablet.

Nimesil® as granules for the preparation of a suspension for oral administration 100 mg., 30 pcs. (Nimesil gran. d/susp. 100 mg 2 g No. 30) - 670 - 900 rubles, online pharmacies offer analogues in a cheaper price segment.

What patients say about Nimesil

1. Irina. The only painkiller I have in my home medicine cabinet is Nimesil. It is really better than all other analgesics. More effective, helps very quickly. Previously, I bought analgin tablets, citramon and similar drugs. But the most they can help with is a mild headache. If you compare Nimesil with other painkillers, then it is a doubly winner. Firstly, Nimesil is a strong pain reliever, and secondly, Nimesil is a safe medicine. For example, if you take Ketanov, then this drug is quite harmful. For me Nimesil is No. 1;
2. Ivan. After my wisdom tooth was removed, I just live on Nimesil, we tried Nurofen, but it doesn’t help at all. And the next day they also cut out the papilloma, and the dentist and surgeon, both doctors, recommended taking Nimesil and indeed, after 20-40 minutes. the pain goes away, lasts for 5-6 hours. Before that I was saved by ketanov, but the doctor categorically forbade it, because this drug is a very strong painkiller and has too many side effects, but in fact I don’t see the point in it, since Nimesil is in comparison with Ketanov it works no worse, and maybe even better;
3. Anastatsia. I have been familiar with Nimesil powder for a long time. At the first symptoms of a cold, for example, poor general condition, low temperature, he always came to the rescue, and even with a high temperature and an illness that had already begun, Nimesil quickly relieved the symptoms - using the drug put me back on my feet in a few days. Once, my gums became inflamed, with swelling of the cheek and pain in the throat and ear, near the wisdom tooth, an operation was performed to cut the hood, but recovery was accompanied by high fever, and here Nimesil also helped me. It comes in the form of a packet of powder and is easy to prepare – just add hot water, stir and drink. It has a slightly sweet and sour, not cloying taste. The drug has helped me more than once, and I noticed that it is much more effective than other powders for colds;
4. Diana. I use it in high temperatures. Powder in bags. Twice a day. Dilute in hot water and drink. It will relieve the fever and aches in the joints too. Not very good for liver function, but no worse than other drugs). After taking the solution, you feel slightly sleepy. Both for viruses and colds - it will ease the symptoms, and maybe put you back on your feet;
5. Julia. For toothache, when I read several interesting publications of Nimesil, Nimid turned out to be the best analgesic and anti-inflammatory drug. Do not rinse a teaspoon of salt into a glass of warm water, but put it in your mouth and hold it until it cools down. Dentists do not allow rinsing; the inflammatory process can go inside;
6. Dmitriy. One evening after dinner my tooth began to ache. Out of habit, I tried to pick at my tooth with a toothpick. But somehow I was getting worse and worse, but not to such an extent that I needed to go to the hospital at night. I asked my wife to look for something for the pain. But as always, there was nothing in the first aid kit. And the 24-hour pharmacy is located on the other side of the city. But my wife says that when she has women’s days, she takes Nimesil and an online pharmacy helped her with this; she once bought the medicine there. She brought me instructions and said that it is also taken for toothache. Indeed, after 10 minutes the pain subsided. A good remedy helps instantly;
7. Ksenia. I first discovered Nimesil powder when I had a toothache. After visiting the dentist, my tooth started to hurt. I came to him again, he said that this could happen within three days and prescribed the use of Nimesil powder. I bought 6 sachets, because I didn’t need more, and a whole package is expensive, because there are 30 sachets. I drank Nimesil after meals, diluting it in half a glass of water twice a day. The pain subsided within 15 minutes. It turns out that Nimesil can be taken not only for pain, but also as an antipyretic and anti-inflammatory. When I was sick with ARVI, I just bought this powder for myself to relieve my body temperature. Also, the action begins after 15 minutes. The powder tastes pleasant, with a lemony taste. There were no side effects when taking the drug. But it should not be taken frequently as it may cause stomach irritation. Therefore, it is important to drink it after meals. The cost of Nimesil powder for 6 sachets is 120 rubles, that is, the whole pack costs 600 rubles.

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One of the means of choice for eliminating acute pain syndrome is Nimesil powder. This drug has a good short-term effect, but is dangerous due to the potential for many side effects. The best recommendation in this case would be to refrain from self-prescribing potent drugs.

The bag contains small granules for preparing a suspension. The taste of the drink is improved by orange flavoring, sweetener and citric acid. To maintain the suspension structure, macrogol polymer and maltodextrin are added to the powder.

The main active component is the substance nimesulide. A serving prepared from one sachet contains 0.1 g of this component.

Pharmacological properties and indications for use

When answering the question of what Nimesil helps with, you should immediately say that it does not have a therapeutic effect - the suspension is drunk as a pain reliever.

It relieves sensations in the following conditions:

• joint pain;
• pain during the menstrual cycle;
• acute muscle pain, including after injuries and sprains;
• pain syndrome due to inflammation of teeth and gums.

The active component blocks receptors sensitive to pain mediators.

As a result, when inflammatory agents are released into the intercellular space, the nerve endings simply cease to perceive them. The acute sensations are suppressed, the pain gradually subsides.

In addition, the same component acts in another direction - it reduces the production of substances formed during inflammation. Thus, not only the pain syndrome subsides, but also the redness, swelling, and swelling of the tissues disappear.

Age restrictions for admission

Powder for oral administration is prohibited for children under twelve years of age due to its high toxicity.

Nimesil powder: instructions for use

This substance is a potent one. Its incorrect dosage can have far-reaching negative consequences. The likelihood of adverse reactions can be reduced by reducing the duration of administration.

How to dilute Nimesil powder

The granules dissolve best in warm water. They are placed in a glass and filled with one hundred milliliters of liquid. The prepared product is not stored, but consumed immediately.

Dosage regimen

The contents of one package are used once. This is a standard one-time rate. Everyone, starting from the age of twelve, is prescribed the same dosage.

You can take Nimesil in an amount of no more than two sachets per day. The course of treatment should not exceed twelve days.

To avoid side effects, you should try to minimize the daily consumption of the drug and the duration of the entire treatment.

Special instructions for use

• During long-term use of the drug, it is necessary to monitor the condition of the kidneys and blood count.
• In persons with gastrointestinal diseases, problems may worsen while taking it. At the first appearance of signs of intoxication and digestive upset, further treatment should be abandoned.
• In patients with impaired renal and liver function, individual dosage adjustments are required. There are no such measures for older persons.

Eating food does not affect the degree of absorption of the active substance. But in order to avoid complications from the digestive tract, the prepared suspension must be drunk after meals.

In practice, cases of sharp deterioration in vision during treatment have been recorded. If you have any eye problems, you should stop taking the powder.

If during treatment the body temperature rises or respiratory infections occur, further use of the drug should be discontinued.

Drug interactions with other drugs

1. The active substance partially inhibits the production of platelets and promotes blood thinning. Its use is contraindicated with the simultaneous administration of drugs that perform the same function. Violation of these requirements is fraught with the opening of internal bleeding.
2. The powder can reduce the effectiveness of diuretics and prevent the removal of salts from the body.
3. The medicine increases the toxicity of antibiotics and antitumor drugs. Their simultaneous use has a destructive effect on the liver. For the same reason, the suspension is not compatible with alcohol.
4. With the simultaneous use of powder and vasodilators that lower blood pressure, enzymes that suppress kidney activity can accumulate. As a result, kidney failure develops as a side effect.
5. The active substance competes with antidiabetic drugs. For this reason, taking them together is unacceptable.

Contraindications, side effects

The drug in question has an impressive list of contraindications.

Its use is canceled if the patient has had or continues to have:

• inflammatory diseases of any part of the digestive tract, complicated by ulcers, erosions, perforation of the wall, bleeding;
• serious disturbances in the functioning of the excretory system;
• pathological conditions of the liver;
• poor susceptibility to non-steroidal analgesics;
• aspirin poisoning;
• allergy to other anti-inflammatory drugs;
• pathologies of the hematopoietic system with coagulation disorders;
• any hay fever, sinusitis, respiratory diseases;
• fever;
• body temperature different from normal;
• surgical intervention in the functioning of the heart and blood vessels;
• hypertension, type 2 diabetes mellitus;
• pregnancy and lactation period.

Alcoholism and smoking should be highlighted as a separate line of contraindications. The drug has a strong effect on the liver. It should not be prescribed to those who have ever had this organ subjected to chemical destruction in the past.

Reactions to the substance include:

• allergies, dermatitis of varying severity, up to tissue rejection;
• blood picture disturbances with a sharp decrease in the number of red blood cells and an increase in inflammation and allergic reactions;
• decreased visual acuity;
• changes in heart function with rhythm disturbances, changes in blood pressure;
• nervous attacks, dizziness, decreased performance, disruption of brain function, feeling of fear at night;
• breathing disorder;
• general malaise;
• exacerbation of intestinal diseases;
• delayed urine production;
• weakening of liver and kidney function;

This list does not include individual reactions to the drug.

Suspension analogues include the following drugs:

• "Aponil";
• "Nise";
• "Nimegesic";
• "Nimesulide";
• "Nimid";
• "Nimulid".

Basically, the analogues are drugs of Indian origin, which are superior in price to the powder in question. All medications on the list have the same active ingredient, so they have similar instructions for use. Medicines are dosed according to the same principle.

• Aponil is produced in Cyprus. It has a dosage form of tablets. One unit of the drug contains 100 mg of active substance. Like all medications in this series, it is available with a doctor's prescription.
• "Nise" is produced in the form of half and whole dose tablets. Also available as a topical 1% gel. In the case of the gel, it is necessary not to exceed the permissible ten-day course of treatment. In this form, the drug can only be applied to undamaged skin.
• “Nimegesic” is a ready-made suspension with the aroma of ripe melon. For use in adults. The one-time norm is two caps. The bottle contains 60 ml of medicine.
• "Nimesulide" - tablets 100 mg. Rarely sold in pharmacies in gel form. It is used in a similar way with “Nise”.
• “Nimid” is a product of Indian origin in the form of sachets and external gel. Dosages and method of use are exactly the same as for similar drugs.
• "Nimulid" is an Indian analogue. It is found in tablets, in the form of an external gel and a ready-made suspension. Previously recommended for children as the most powerful antipyretic. Later it turned out that the reception is not compatible with high temperature.

Now all drugs based on this active substance are prohibited for use in children under 12 years of age.

The powder in question has a pronounced analgesic property. Reviews about its use are mostly positive. But do not forget that this drug greatly complicates the functioning of the liver. Therefore, if possible, long-term treatment should be avoided.

Nimesil belongs to the group of anti-inflammatory drugs. The effects that are characteristic of this medicine are antipyretic, anti-inflammatory, analgesic. The peculiarity of the medicine is that it is quite well tolerated by the body during long-term therapy.

Composition and release form

Release form

Nimesil is available in the form of granules for administration as a suspension of 100 mg in a sachet for single oral use.

Composition of the product

• Active substance: nimesulide 100 mg;
• Excipients: ketomacrogol 1000, sucrose, maltodextrin, anhydrous citric acid, orange flavor.

Storage: Nimesil is stored in a dry place, protected from light, where a constant temperature is maintained no higher than 25 degrees. Shelf life – 2 years. After the expiration date, this product cannot be used.

pharmachologic effect

Nimesil belongs to the group of sulfonamides. The main active substance is nimesulide. After ingestion, the active substance is absorbed into the body, reaching maximum concentration after 2 hours. The percentage of binding to plasma proteins is about 97.5%. Half-life – 3.2-6 hours.

Nimesil is metabolized in liver cells, the main metabolite is the parahydroxy derivative of nimesulide, which is a pharmacologically active substance. Hydroxynimisulide is metabolized in the liver and excreted in the bile. Nimesulide is excreted from the body as a result of kidney function in the amount of about 50% of the dose taken.

Treatment of patients with renal failure. Recommended doses for severe renal failure should not be reduced. Experimental studies have not shown any deviations when using Nimesil in such patients.

Indications for use of Nimesil

• pain syndromes, the cause of the appearance does not matter.
• acute pain that accompanies tendonitis and bursitis;
• osteoarthritis, rheumatoid arthritis, the symptom of which is pain;
• primary dysmenorrhea;
• diseases of the hearing organs, upper respiratory tract and throat;
• gynecological diseases that are accompanied by pain syndromes and fever;
• recovery period after surgical interventions, including dental ones;
• injuries.

Contraindications

• hypersensitivity to the components of the drug;
• rhinitis, bronchispasm, urticaria (in history, when taking non-steroidal anti-inflammatory drugs, for example, acetylsalicylic acid);
• history of toxic reactions of liver cells to Nimesil components;
• chronic form of gastric and duodenal ulcers during exacerbation;
• cerebrovascular bleeding;
• any conditions of the body that are accompanied by bleeding from the gastrointestinal tract;
• severe bleeding disorders;
• heart, kidney and liver failure;
• age under 12 years;
• pregnancy and lactation period.

Side effects

• disorders of the gastrointestinal tract, which is expressed by nausea, vomiting and diarrhea;
• anemia;
• eosinophilia;
• hyperkalemia;
• heart rhythm disturbances;
• dizziness;
• frequent surges in blood pressure;
• skin rashes that are accompanied by itching;
• gastritis;
• hematuria;
• problems with urination;
• visual impairment;
• constant feeling of fear and nightmares;
• nervousness and irritability;
• increased levels of liver transaminases.

Instructions for use

Method and dosage

Nimesil is prescribed exclusively to adult patients. The method of administration of the drug is oral. Take only after meals.

The recommended daily intake is about 200 mg, which should be divided into two doses of 100 mg. Before use, you must first prepare it. To do this, the contents of the bag must be combined with warm water. The dose is increased only if necessary. The dose may be adjusted depending on the body's response to the components of the drug. For elderly people, the dose of Nimesil should be reduced, depending on the patient’s condition

The maximum duration of treatment with this drug is 15 days. To avoid the occurrence of overdose symptoms and side effects, the minimum dose of the drug should be used for treatment, at which the desired effect occurs in the shortest possible course.

Nimesil for toothache

Nimesil is a fairly effective drug for eliminating attacks of acute toothache as a result of the development of caries or in the presence of infection in the soft tissues of the oral cavity. Inflammatory processes that occur in dental tissue, so-called pulpitis, can cause severe pain and if you do not consult a doctor in time, complications will inevitably develop that can lead to tooth loss. That is why, in case of severe pain, it is not recommended to use Nimesil constantly, since eliminating the symptom is not a complete treatment.

The human body tends to get used to various types of medications and, after prolonged use of the medication, stops responding to the active substance. That is, the drug loses its effectiveness. To relieve an attack of acute toothache, you need to take Nimesil in an amount of 100 mg twice a day on a full stomach. The prepared solution cannot be stored, so a new one must be prepared before use.

Nimesil for children

During pregnancy and lactation

The active substance of the medication may have a negative effect on the course of pregnancy itself and on the development of the fetus. The result of this effect is premature closure of the ductus arteriosus, pulmonary hypertension, renal dysfunction, including renal failure, increased risk of bleeding, edema and decreased uterine contractility.

Due to the presence of high risks, both for the health of the baby and for the expectant mother, taking Nimesil during pregnancy and breastfeeding is contraindicated. Women planning their pregnancy should refuse treatment with this drug due to the effect of its components on female fertility.

Overdose

The instructions note that the symptoms of an acute overdose of Nimesil are the following conditions:

• drowsiness;
• apathy towards everything:
• constant feeling of nausea, periodic vomiting;
• pain in the epigastric region;
• gastrointestinal bleeding;
• arterial hypertension;
• breathing problems;
• renal failure;
• coma.

Treatment: all side effects are easily reversible with appropriate symptomatic treatment.

Interaction with other drugs

• GCS. Joint use with Nimesil increases the risk of ulcers and bleeding of the gastrointestinal tract.
• Fluoxetine and other antiplatelet agents. The risk of gastrointestinal bleeding increases.
• Anticoagulants. Combined use may lead to an increase in the effect of the main active substance. It is not recommended to combine Nimesil with drugs in this category for people with coagulation disorders due to the increased risk of bleeding. If this is not possible, then the patient's condition must be constantly monitored.
• Diuretics. Nimesil may reduce the effect of diuretics. The active substance may reduce the excretion of sodium and potassium under the influence of furosemide. When furosemide and Nimesil are prescribed simultaneously to patients with impaired cardiac and renal function, additional monitoring is required.
• ACE inhibitors. When these drugs are combined with Nimesil, the effect of the former is reduced. In the presence of renal failure, regardless of the degree of the disease, kidney function deteriorates. With timely treatment, acute renal failure is reversible.
• Lithium preparations. Nonsteroidal anti-inflammatory drugs can increase the concentration of lithium in the patient's blood. If Nimesil is prescribed within 24 hours after taking methotrexate, since when taken together, the toxicity of the latter drug may increase.

The active substance is displaced by salicylic and valproic acid, tolbutamide from the binding sites.

Domestic and foreign analogues

Actasulide

The active ingredient is nimesulide. One tablet of the drug contains 100 mg. It is a non-steroidal anti-inflammatory drug that can inhibit the synthesis of prostaglandins at the site of the inflammatory process. This analogue of the drug Nimesil is prescribed for joint diseases: rheumatoid arthritis, articular syndrome with chronic gout during an exacerbation, psoriatic arthritis and others. Used to treat patients over 12 years of age in the amount of 1 tablet twice a day.

Yellowish tablets, the main active ingredient of which is nimesulide. Has anti-inflammatory, antipyretic, analgesic effects. Like Nimesil, it is indicated for pain syndromes that accompany joint diseases. This analogue is indicated for the elimination of symptomatic pain due to inflammatory processes. It should be taken after meals in an amount of 50-100 mg, depending on the severity of the pain syndrome, twice a day.

Each Apolin tablet contains 100 mg of nimesulide and excipients. Taking Apolin is indicated for symptomatic expressions of pain and fever, regardless of the cause of origin.

An analogue of Nimesil, which contains 50 or 100 mg of nimesulide, depending on the release form. This drug is a representative of the group of non-steroidal anti-inflammatory drugs. Has anti-inflammatory and antipyretic effect. This analogue is taken orally, which ensures good absorption. According to the instructions, the daily norm is 100 mg. This drug can be used for children: 1.5 mg per 1 kg of child’s weight, dividing the resulting amount into 3 doses. Before taking, it is advisable to dissolve the tablets in 1 tsp. warm water.

Price in pharmacies

The price of Nimesil in different pharmacies may vary significantly. This is due to the use of cheaper components and the pricing policy of the pharmacy chain.

Read the official information about the drug Nimesil, the instructions for use of which include general information and a treatment regimen. The text is provided for informational purposes only and cannot serve as a substitute for medical advice.

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