Mefenamic acid: instructions for use and reviews
Latin name: Mefenamic acid
ATX code: M01AG01
Active substance: mefenamic acid
Manufacturer: Flamingo Pharmaceuticals Ltd., India
Updating the description and photo: 13.08.2019
Mefenamic acid is a drug with analgesic, antipyretic and anti-inflammatory effects.
Release form and composition
Mefenamic acid is produced in the form of tablets (in blister packs of 10 pcs., 1 or 2 packs in a cardboard box).
1 tablet contains:
- Active substance: Mefenamic acid – 0.5 g;
- Auxiliary components: octadecanoic acid, potato starch, methylcellulose, croscarmellose sodium, magnesium stearate.
Pharmacological properties
Pharmacodynamics
Mefenamic acid is a derivative of anthranilic acid and belongs to the group of antirheumatic and nonsteroidal anti-inflammatory drugs. The drug is able to reduce the intensity of the body's production of specific inflammatory mediators - prostaglandins and serotonin. Mefenamic acid affects both the central mechanisms of increasing pain sensitivity and processes occurring in the periphery, and also suppresses the activity of lysosome proteases.
Mefenamic acid helps stabilize cell membranes and protein ultrastructures, eliminates swelling and reduces capillary permeability. The antipyretic effect of the active component of the drug is explained by its ability to influence the thermoregulation center located in the brain and suppress the production of inflammatory mediators.
Mefenamic acid is also characterized by a moderate antiviral effect due to stimulation of interferon synthesis and an increase in the concentration of T-lymphocytes and T-helper cells.
Pharmacokinetics
After oral administration of mefenamic acid, its maximum concentration in the blood is reached after approximately 3 hours. The content of the substance in the blood plasma directly depends on the dose taken (there is a linear relationship). Mefenamic acid is highly protein bound and metabolized in the liver. The half-life is 120–240 minutes, and the drug is excreted in urine and feces.
Indications for use
- Symptomatic treatment of pain syndrome;
- Influenza and acute respiratory viral infections (simultaneously with other drugs);
- Feverish conditions (as an antipyretic);
- Inflammatory disorders of the osteoarticular system: rheumatism, rheumatoid arthritis, ankylosing spondylitis;
- Pain, inflammation and swelling developing in the post-traumatic and postoperative periods;
- Blood loss during menorrhagia, which is caused by ovulatory dysfunctional bleeding in the absence of pathologies of the pelvic organs;
- Functional dysmenorrhea.
Contraindications
- Functional disorders of the kidneys and liver;
- Inflammatory diseases of the gastrointestinal tract;
- Peptic ulcer of the stomach and duodenum;
- Blood diseases;
- Age up to 5 years;
- Pregnancy and lactation (breastfeeding);
- Hypersensitivity to the components of the drug.
Instructions for use of Mefenamic acid: method and dosage
Mefenamic acid is taken orally after meals.
A single dose is determined by age:
- Adults and children over 12 years of age: 0.25-0.5 g (maximum daily dose – 3 g, with improvement, reduce the dose to 1 g);
- Children 5-12 years old: 0.25 g.
The frequency of taking the drug is 3-4 times a day.
The doctor determines the duration of treatment individually (on average 20-60 days). When carrying out symptomatic treatment of pain syndrome, the drug is usually used for up to 7 days.
Side effects
Most often, during the use of Mefenamic acid, gastrointestinal disorders occur, manifested as dyspepsia, gastrointestinal discomfort, epigastric pain, diarrhea, and increased levels of liver enzymes. Taking the drug can lead to the development of stomach ulcers and gastrointestinal bleeding.
The following side effects may also occur during therapy:
- Cardiovascular system: increased blood pressure, rhythm disturbances, peripheral edema; rarely – congestive heart failure;
- Central nervous system: very rarely – irritability, sleep disturbance;
- Genitourinary system: nonspecific inflammation of the kidneys, functional disorders of the kidneys, dysuria, albuminuria, hematuria;
- Respiratory system: bronchospasm, dyspnea;
- Hematological effects: eosinophilia, agranulocytosis, thrombocytopenic purpura or thrombocytopenia, hemolytic anemia;
- Allergic reactions: urticaria, skin rash.
Overdose
Symptoms of an overdose of Mefenamic acid include drowsiness, decreased blood pressure, nausea, vomiting, gastrointestinal bleeding, pain in the abdomen, depression of the respiratory center, convulsions, coma.
The active component of the drug does not have a specific antidote. When taking too high doses of Mefenamic acid, it is recommended to rinse the stomach and take enterosorbents. Acidification of urine and forced diuresis are also indicated. The effectiveness of hemodialysis in this case remains insignificant.
special instructions
According to the instructions, Mefenamic acid should not be taken by patients with allergies to aspirin and non-steroidal anti-inflammatory drugs, severe heart failure, ulcers, intestinal perforation, severe liver cirrhosis, or after heart surgery.
The drug should be taken with caution by elderly patients, as well as by epilepsy, dehydration, allergies, asthma, diabetes, circulatory disorders, risk of stroke, angina pectoris, bleeding disorders, porphyria, decreased liver or kidney function. This group of patients may require a dose reduction or change in therapy regimen.
To reduce irritation of the gastric mucosa, the drug is recommended to be taken with meals. It is also possible to reduce the dose taken if necessary. If skin rashes or diarrhea develop, the drug should be interrupted.
With prolonged treatment, blood counts and kidney and liver function should be monitored.
While using Mefenamic acid, it is not recommended to drive vehicles or perform work that requires high attention and rapid psychomotor reactions.
Use in childhood
Mefenamic acid is not prescribed to children under the age of 5 years.
The maximum daily dose of Mefenamic acid for children aged 5 to 12 years is 1 g. Usually prescribed 250 mg 3-4 times a day. The duration of therapy is determined by the doctor.
Drug interactions
When using Mefenamic acid simultaneously with certain medications, undesirable effects may occur:
- Opioid analgesics, dicoumarin, vitamins B6, B1, phenothiazine derivatives: increased effect of Mefenamic acid;
- Anticoagulants, vitamin K antagonists: enhancing their effect;
- Methotrexate: strengthening of its negative effects;
- Warfarin, non-steroidal anti-inflammatory drugs: increased risk of gastrointestinal disorders;
- Antacids: increased bioavailability of Mefenamic acid, increased side effects.
Analogs
Analogues of Mefenamic acid are: Mefenamic acid-Darnitsa, Jenospa.
Terms and conditions of storage
Store out of the reach of children at temperatures up to 25 °C.
What is mefenamic acid? Today, the drug is very popular in arthrology, in the treatment of infectious and inflammatory diseases.
Pharmacological properties of the drug, as well as indications and contraindications for use, analogues and cost in this article.
Mefenamic acid. General information
It is an anti-inflammatory, analgesic, antiviral drug.
The drug is widely used in arthrology for the treatment of infectious and inflammatory diseases.
Pharmacological properties
Mefenamic acid is a derivative of anthranilic acid, belonging to the group of non-steroidal anti-inflammatory and antirheumatic drugs.
It affects the central and peripheral mechanisms of pain, reduces the local inflammatory process.
Helps lower temperature due to its effect on the thermoregulation center. The anti-inflammatory effect is obtained by stimulating the production of interferons. The effect of taking the drug occurs after three hours. Mefenamic acid is excreted from the body in the urine.
Composition and release form
Mefenamic acid is a bitter, gray-white powder, odorless.
Available in the form of tablets of 10 pieces in one cell, one or two packages in a cardboard box.
Active ingredient: mefenamic acid.
Excipients: talc lactose monohydrate, corn starch sodium lauryl sulfate; silicon dioxide; magnesium stearate.
Indications
Contraindications
Mefenamic acid should not be used if:
Carefully:
- - patients with epilepsy;
- - hypertension;
- - nonspecific ulcerative colitis;
Side effects
- — Has undesirable effects on the central nervous system: drowsiness, weakness, irritation, convulsions, headaches;
- - nausea, vomiting, gas formation;
- - colitis, heartburn, hepatitis, jaundice, enterocolitis, pancreatitis;
- - high or low blood pressure;
- - arrhythmia;
- - gastritis;
- - bronchospasm;
- - cystitis;
- - renal failure.
Use of mefenamic acid
Way
Mefenamic acid is indicated to be taken orally during meals. The tablet or capsule must not be split; it must be swallowed whole.
Dosage: adults 250 mg or 500 mg 3-4 times a day. The maximum daily dose is 3 grams.
The duration of the course of treatment is prescribed by the attending physician.
The daily dose of mefenamic acid for children aged five to twelve years should not exceed 1 gram. The exact dosage and duration of the course are determined by the attending physician.
Overdose
The drug is quickly absorbed into the gastrointestinal tract, so in case of overdose, there may be: ulcers, gastrointestinal erosions.
Accompanied by the following symptoms: vomiting, nausea, increased or decreased blood pressure, difficulty breathing, coma.
In case of an overdose of the drug, it is necessary to: induce vomiting, take sorbents.
special instructions
Mefenamic acid should not be taken by patients with allergies to the components of the drug and non-steroidal anti-inflammatory drugs, heart failure, after heart surgery and with cirrhosis of the liver.
With caution: elderly people, patients with diabetes mellitus, circulatory disorders, bronchial asthma, stroke. This group of patients is prescribed the drug with a minimum dosage.
To reduce side effects on the gastrointestinal tract, mefenamic acid should be used during or after meals. If skin rashes and nausea occur, the drug should be interrupted.
Analogs
Preparations identical in composition and indications for use
Other analogues of the drug
Storage conditions
Store at temperatures up to 25 degrees, out of the reach of children.
Conditions for dispensing from pharmacies.
Dispensed without a doctor's prescription.
Price
The cost of the drug depends on the form and packaging.
Average price: 240-300 rubles.
Name:
Mefenamic acid (Acidum mefenamicum)
Pharmachologic effect:
Mefenamic acid belongs to the group of NSAIDs and is a derivative of anthranilic acid, has analgesic, anti-inflammatory and antipyretic properties. Inhibits the synthesis of prostaglandins and serotonin, providing an anti-inflammatory effect. It affects both the central mechanisms of pain sensitivity and the peripheral ones, causing a decrease in local inflammation in the area. Stabilizes protein structures and cell membranes, reducing the permeability of the vascular wall. Reduces cell proliferation in the inflammatory focus, which stimulates healing.
The antipyretic effect is due to the effect on the thermoregulation center and a decrease in the production of prostaglandins.
Antiviral effect – stimulates the formation of interferon, increases the ratio of T-helper cells, increases the activity of T-lymphocytes.
When taken orally, the drug is quickly absorbed into the gastrointestinal tract. The peak is observed after 2-4 hours, the increase in blood concentration is directly proportional to the dose taken. There is a high connection with blood proteins (albumin) up to 90%. Metabolized in the liver. Period T ½ 120-240 minutes. Eliminated in urine and partially in feces.
Indications for use:
Symptomatic treatment of pain syndrome,
Inflammatory processes of the osteoarticular system: rheumatoid arthritis, rheumatism, ankylosing spondylitis,
Post-traumatic and post-operative manifestations such as pain, swelling and inflammation,
Blood loss during menorrhagia caused by ovulatory dysfunctional bleeding in the absence of pathology of the pelvic organs,
Functional dysmenorrhea,
In febrile conditions as an antipyretic,
For complex therapy of influenza and ARVI.
Method of application:
Children age group from 5 to 12 years: 250 mg three to four times a day. The duration of therapy is from 20 to 60 days or more.
For symptomatic treatment of pain, a short-term course of treatment is up to 7 days.
Adverse events:
The most common side effects are changes in the gastrointestinal tract, which are accompanied by dyspepsia, gastrointestinal discomfort, pain in the epigastric region, diarrhea, increased levels of liver enzymes, and can also provoke stomach ulcers and gastrointestinal bleeding.
Negative hematological effects have been noted: hemolytic anemia, agranulocytosis, eosinophytosis, thrombocytopenia or thrombocytopenic purpura.
Changes in cardiovascular system: rhythm disturbances, increased blood pressure, peripheral edema, rarely congestive heart failure.
Changes in the respiratory system are accompanied by bronchospasm and dyspnea.
Changes in the urinary system: dysuric manifestations, nonspecific inflammation of the kidneys, impaired renal function, albuminuria, hematuria.
CNS changes: very rarely, sleep disturbance and irritability.
Allergic reactions are manifested by hives and skin rashes.
Contraindications:
Individual intolerance to the drug,
Peptic ulcer of the stomach and duodenum,
Inflammatory processes of the gastrointestinal tract,
Liver and kidney dysfunctions,
Blood diseases
Pregnancy,
Lactation period
Children's age group up to 5 years.
During pregnancy:
Pregnancy and breastfeeding are contraindications for the use of mefenamic acid.
Interaction with other drugs:
Mefenamic acid affects platelet function, which may enhance the effect of anticoagulant therapy and vitamin K antagonists.
Dicoumarin, opioid painkillers, vitamin B6, B1, phenothiazine derivatives can enhance the effect of mefenamic acid.
Methotrexate has more pronounced negative effects when taken simultaneously with mefenamic acid.
NSAIDs, warfarin in combination with the use of mefenamic acid increase the risk of developing gastrointestinal disorders.
Antacids increase the bioavailability of mefenamic acid, which increases its side effects.
Overdose:
Mefenamic acid in overdose has a strong tendency to provoke acute erosions or ulcers of the gastrointestinal mucosa, and in rare cases, tonic-clonic convulsions. Treatment: symptomatic therapy, sorbents, gastric lavage, forced diuresis, urine alkalization. There is no specific antidote. Hemodialysis is not effective due to the strong connection of the drug with albumin.
Release form of the drug:
Tablets p/o 500 mg in contour cells No. 10.
Cardboard packaging No. 10, No. 20.
Storage conditions:
Stored at a temperature of no more than 25 °C.
Compound:
The active substance is mefenamic acid.
1 tablet contains acidum mefenamicum - 500 mg
Excipients: potato starch, methylcellulose, croscarmellose Na, octadecanoic acid, magnesium stearate.
Additionally:
Mefenamic acid should not be used in patients who are allergic to aspirin or NSAIDs, have had heart surgery, have severe heart failure, ulcers, intestinal perforations, or severe cirrhosis of the liver.
Patients who may experience complications during treatment: the elderly, manifestations of dehydration, epilepsy, allergies, asthma, risk of stroke, angina pectoris, circulatory disorders, diabetes mellitus, bleeding disorders, porphyria, or decreased liver or kidney function. These situations may require dose reduction or treatment changes.
To reduce irritation of the gastric mucosa, the dose of the drug may be reduced, and it is also recommended to take mefenamic acid with meals.
Drug therapy should be discontinued if diarrhea or skin rashes occur.
With long-term therapy, it is necessary to monitor blood counts and liver and kidney function.
Mefenamic acid reduces the rate of reactions and driving is not recommended during therapy. Not applicable to children under 5 years of age.
Drugs with similar effects:
Diclo-F Remisid Rapten gel Rapten Dolgit
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Thank you very much!Instructions for medical use of the drug
Description of pharmacological action
Blocks cyclooxygenase and inhibits PG synthesis.
Indications for use
Pain (headache, neuralgia, arthralgia, myositis) and fever syndromes.
Release form
tablets 0.5 g; contour cell packaging 10, cardboard pack 5;
Pharmacodynamics
Suppresses the synthesis of inflammatory mediators (PG, serotonin, kinins, etc.), reduces the activity of lysosome proteases, which take part in the inflammatory reaction. It flows into the phases of exudation and proliferation. Stabilizes protein ultrastructures and cell membranes, changes the penetration of blood vessels and the laxity of tissues. Rose is a phosphorylated oxide, inhibits the synthesis of mucopolysaccharide. Suppresses the pro-inflammatory activity of serotonin. It stimulates the proliferation of cells at the site of inflammation, promotes cell resistance and stimulates healing of wounds. In pain. severe effect, in order with the influx on the central mechanisms of pain sensitivity, the main role is played by the mescial influx on the cavity burning, production inhibits the algogenicity of endogenous substances (kinins, histamine, serotonin). Stimulates the creation of interferon.
Pharmacokinetics
After oral administration, it is quickly and fairly completely absorbed, creating Cmax after 2–4 hours. The level in the blood is proportional to the dose. The equilibrium concentration (20 mcg/ml) is determined on the 2nd day of use (1 g 4 times a day). In the vascular bed it binds to albumin. T1/2 - 3 hours. In the liver it forms a number of metabolites (oxidized, hydrolyzed, glucuronidated). 67% of the dose taken is excreted in the urine unchanged or in the form of biotransformation products, 20–25% in feces.
Use during pregnancy
The drug is contraindicated during pregnancy. If it is necessary to use the drug during breastfeeding, breastfeeding should be discontinued.
Contraindications for use
Hypersensitivity, peptic ulcer of the stomach and duodenum, gastritis.
Side effects
Nausea, diarrhea, allergic reactions.
Directions for use and doses
Orally, after meals - 0.5 g 3-4 times a day; children 5–10 years old - 0.25 g, over 10 years old - 0.3 g.
Overdose
Symptoms: pain in the epigastric region, nausea, vomiting, drowsiness. In severe cases, gastrointestinal bleeding, respiratory depression, hypertension, twitching of individual muscle groups, coma.
Treatment. There is no specific antidote. Gastric lavage with a suspension of activated carbon. Alkalinization of urine, forced diuresis. Symptomatic therapy. Hemosorption and hemodialysis are ineffective due to the strong binding of mefenamic acid to blood proteins.
Interactions with other drugs
Salicylates and metamizole sodium enhance the anti-inflammatory effect. Thiamine, pyridoxine, barbiturates, phenothiazine derivatives, narcotic analgesics, caffeine, phenacetin, diphenhydramine potentiate analgesia. Prolongs prothrombin time and increases the effectiveness of oral anticoagulants.
Precautions for use
Not recommended for use during pregnancy, because It is quite likely to have an effect on the cardiovascular system of the fetus. May pass into breast milk, which limits use in nursing women. To prevent complications from the gastrointestinal tract, it is recommended to take it after meals and wash it down with milk. It should be borne in mind that cross-sensitization with other NSAIDs cannot be ruled out. If diarrhea develops, it is necessary to reduce the dose of mefenamic acid or temporarily discontinue it.
Storage conditions
List B.: In a dry place, protected from light.
Best before date
ATX classification:
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Mefenamic acid - NSAIDs. The mechanism of anti-inflammatory action is due to the ability to inhibit the synthesis of inflammatory mediators (prostaglandins, serotonin, kinins, etc.) and reduce the activity of lysosomal enzymes involved in the inflammatory reaction. Mefenamic acid stabilizes protein ultrastructures and cell membranes, reduces vascular permeability, disrupts the processes of oxidative phosphorylation, suppresses the synthesis of mucopolysaccharides, inhibits cell proliferation at the site of inflammation, increases cell resistance and stimulates wound healing. Antipyretic properties are associated with the ability to inhibit the synthesis of prostaglandins and influence the thermoregulation center.
Mefenamic acid stimulates the formation of interferon.
In the mechanism of analgesic action, along with the influence on the central mechanisms of pain sensitivity, a significant role is played by the local effect on the site of inflammation and the ability to inhibit the formation of algogens (kinins, histamine, serotonin). Pharmacokinetics
.
After oral administration, mefenamic acid is quickly and fairly completely absorbed from the digestive tract. The maximum concentration in the blood is achieved 2 - 4:00 after administration. The blood level is proportional to the dose. The equilibrium concentration (20 mcg/ml) is determined on the second day of use (1 g 4 times a day). Binds 90% to blood albumin. In the liver it forms metabolites by oxidation, hydrolysis, glucuronidation. The half-life (T 1/2) is 2 - 4:00. It is excreted from the body unchanged and in the form of metabolites mainly by the kidneys (67% of the dose), with feces (20 - 25%).
Indications for use
Indications for use of tablets Mefenamic acid are:- Acute respiratory viral infections and influenza.
- Pain of low and medium intensity: muscle, joint, traumatic, dental, headache of various etiologies, postoperative and postpartum pain.
- Primary dysmenorrhea.
- Dysfunctional menorrhagia, including those caused by the presence of intrauterine contraceptives, in the absence of pathology of the pelvic organs.
- Inflammatory diseases of the musculoskeletal system: rheumatoid arthritis, rheumatism, ankylosing spondylitis.
Mode of application
Apply the drug Mefenamic acid should be under the supervision of a physician, determine the dose and duration of treatment. Use internally. The medicine should be taken after meals with milk.Adults and children over 12 years old: 250 - 500 mg 3 - 4 times a day. According to indications and if well tolerated, the dose is increased to a maximum of 3000 mg; after achieving a therapeutic effect, the dose is reduced to 1000 mg/day.
Children aged 5 to 12 years - 250 mg 3 - 4 times a day.
The course of treatment for joint diseases can last from 20 days to 2 months or more. When treating pain syndrome, the course of treatment lasts up to 7 days.
Children. The drug is contraindicated in children under 5 years of age.
Side effects
On the part of the organ of vision: blurred vision, reverse loss of the ability to distinguish colors, eye irritation.On the part of the hearing and vestibular apparatus: tinnitus, otalgia.
From the respiratory system, chest and mediastinal organs: shortness of breath, bronchospasm.
From the gastrointestinal tract: pain in the epigastric region, anorexia, heartburn, nausea, flatulence, vomiting, enterocolitis, colitis, exacerbation of colitis and Crohn's disease, gastritis, hepatotoxicity, steatorrhea, cholestatic jaundice, hepatitis, pancreatitis, hepatorenal syndrome, hemorrhagic gastritis , ulcer with or without bleeding. Gastrointestinal bleeding, perforation or gastrointestinal bleeding, sometimes fatal, especially in elderly patients, dyspepsia, constipation, diarrhea.
From the kidneys and urinary system: dysuria, cystitis. Impaired renal function, albuminuria, hematuria, oliguria or polyuria, renal failure, including papillary necrosis, acute interstitial nephritis, nephrotic syndrome, allergic glomerulonephritis, hyponatremia, hyperkalemia.
From the nervous system: drowsiness or insomnia, weakness, irritability, agitation, headache, blurred vision, convulsions, optic neuritis, paresthesia, dizziness, stiff neck, fever, loss of orientation.
From the mental side: confusion, depression, hallucinations.
From the cardiovascular system: arterial hypertension, arrhythmia, rarely - congestive heart failure, peripheral edema, fainting, arterial hypotension, palpitations, shortness of breath, thrombotic complications (for example, myocardial infarction or stroke).
From the blood and lymphatic system: aplastic anemia, autoimmune hemolytic anemia, increased bleeding time, eosinophilia, leukopenia, thrombocytopenia, decreased hematocrit, thrombocytopenic purpura, agranulocytosis, neutropenia, pancytopenia, bone marrow hypoplasia.
From the immune system: hypersensitivity reactions, including rash, itching, facial swelling, allergic rhinitis, angioedema, laryngeal edema, Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme, urticaria, bullous pemphigus, photosensitivity, asthma, anaphylaxis.
From the skin and subcutaneous tissue: purpura, skin rashes, itching, erythema multiforme, urticaria, bullous pemphigus.
Laboratory indicators: impaired glucose tolerance in patients with diabetes mellitus, positive reaction in some tests for the presence of mefenamic acid and its metabolites in bile and urine. Increased levels of liver enzymes in blood plasma.
Others: aseptic meningitis, sweating, fatigue, malaise, multiple organ failure, hyperthermia.
Contraindications
Contraindications to the use of the drug Mefenamic acid are:- Hypersensitivity to the components of the drug.
- Bronchospasm, Quincke's edema, rhinitis, bronchial asthma, urticaria in history, which occurred after the use of acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (NSAIDs).
- Simultaneous administration of specific COX-2 inhibitors.
- Peptic ulcer of the stomach and duodenum, including a history of inflammatory bowel disease, diseases of the hematopoietic organs, severe heart failure, severe liver or kidney dysfunction, gastrointestinal bleeding or perforation caused by taking non-steroidal anti-inflammatory drugs.
Pregnancy
A drug Mefenamic acid Do not use in women during pregnancy and breastfeeding.Interaction with other drugs
Thiamine, pyridoxine hydrochloride, barbiturates, phenothiazine derivatives, narcotic analgesics, caffeine, diphenhydramine increase the analgesic effect of the drug.When used together, mefenamic acid and methotrexate increase the toxic effects of methotrexate.
Antihypertensive drugs (ACE inhibitors and angiotensin II receptor antagonists): decreased antihypertensive effect, increased risk of renal failure, especially in elderly patients. Patients should drink enough fluids. It is also necessary to assess renal function at the beginning of treatment and during concomitant therapy.
Diuretics: decreased diuretic effect. Diuretics may increase the nephrotoxicity of NSAIDs.
Cardiac glycosides: NSAIDs may worsen heart failure, reduce glomerular filtration rate and increase plasma levels of cardiac glycosides.
Cyclosporines: increased risk of nephrotoxicity.
Mifepristone: NSAIDs should not be taken for 8 to 12 days after taking mifepristone - NSAIDs may reduce the effects of mefipristone.
Corticosteroids: increased risk of gastrointestinal ulcers and bleeding.
Antiplatelet agents and selective serotonin reuptake inhibitors: increased risk of gastrointestinal bleeding.
Fluoroquinolones: NSAIDs increase the risk of seizures.
Aminoglycosides: NSAIDs increase the risk of nephrotoxicity.
Tacrolimus: possible increased risk of nephrotoxicity.
Zidovudine: NSAIDs increase the risk of hematological toxicity. The risk of joint hemorrhage and hematoma increases in HIV-positive hemophiliacs who are simultaneously treated with zidovudine.
Lithium preparations reduce the excretion of lithium and increase the risk of developing lithium toxicity.
Mefenamic acid increases the activity of oral anticoagulants, so their simultaneous use increases the risk of bleeding. Concomitant use of mefenamic acid with oral anticoagulants requires careful monitoring of prothrombin time. You should take NSAIDs with warfarin or heparin with caution - medical supervision is necessary.
Concomitant use with other NSAIDs increases the anti-inflammatory effect and the likelihood of side effects from the gastrointestinal tract.
Overdose
Symptoms of pill overdose Mefenamic acid: pain in the epigastric region, nausea, vomiting, drowsiness. In severe cases - gastrointestinal bleeding, respiratory depression, arterial hypertension, twitching of individual muscle groups, coma.Treatment. There is no specific antidote. Gastric lavage with a suspension of activated carbon. Alkalinization of urine, forced diuresis. Symptomatic therapy. Hemosorption and hemodialysis are ineffective due to the strong binding of mefenamic acid to blood proteins.
Storage conditions
Store out of the reach of children in the original packaging at a temperature not exceeding 25 ° C.Release form
Mefenamic acid - tablets.Packaging: 10 tablets in a blister pack; 2 contour packs per pack.
Compound
1 tablet Mefenamic acid contains mefenamic acid 500 mg.Excipients: potato starch, methylcellulose, croscarmellose sodium, stearic acid, magnesium stearate.
Additionally
The drug is prescribed with caution to patients with acute cardiovascular failure, arterial hypertension, and coronary heart disease.The drug is prescribed with caution to patients with epilepsy.
Mefenamic acid should be used in patients who have previously experienced hypersensitivity reactions, such as asthma, bronchospasm, rhinitis, angioedema or urticaria.
Do not use in dehydrated patients who have lost fluid due to vomiting, diarrhea, or increased urination.
For long-term treatment of headaches, you should consult your doctor.
For moderate impairment of liver or kidney function, there are no special recommendations for the use of the drug.
NSAIDs should be taken with caution in patients with a history of gastrointestinal diseases (ulcerative colitis, Crohn's disease), since exacerbation of the disease is possible. If the use of mefenamic acid leads to gastrointestinal bleeding and perforation, treatment should be discontinued.
Elderly patients generally have an increased risk of developing gastrointestinal side effects, especially gastrointestinal bleeding and perforation, which can be fatal, so treatment should begin at dosage itself.
Patients with systemic lupus erythematosus and mixed connective tissue diseases are at increased risk of aseptic meningitis.
Mefenamic acid should be used with caution in patients at high risk of serious skin reactions, including exfoliative dermatitis, Stevens-Johnson syndrome and toxic epidermal necrolysis. Mefenamic acid should be discontinued at the first appearance of skin rash, mucosal damage, or any other manifestation of hypersensitivity.
With long-term use of the drug, it is necessary to monitor blood counts, since mefenamic acid can cause pathological changes in the blood. If manifestations of any dyscrasia occur, drug therapy should be discontinued.
Taking mefenamic acid may cause gastrointestinal problems (eg diarrhea). They can occur either immediately after using the drug or after long-term use. If such symptoms occur, you must stop using the drug.
Caution should be exercised when using mefenamic acid in patients receiving therapy with drugs that increase the risk of bleeding: corticosteroids, anticoagulants (warfarin) and aspirin.
Taking mefenamic acid may impair female fertility and is not recommended for women who are trying to become pregnant. When used by women with symptoms of dysmenorrhea and menorrhagia and the absence of a therapeutic effect, it is necessary to consult a doctor.
The ability to influence the reaction rate when driving vehicles or other mechanisms.
Caution should be exercised when driving vehicles or operating machinery that requires increased attention, since sometimes the use of the drug can cause drowsiness, blurred vision, and convulsions.
Main settings
| Name: | MEPHENAMINOIC ACID |
| ATX code: | M01AG01 - |