Controlled release tablets - 1 tablet. trazodone hydrochloride - 75 mg - 150 mg excipients: sucrose; carnauba wax; povidone (polyvinylpyrrolidone); magnesium stearate tablets 75 mg: 30 tablets. - in a cardboard box 1 blister of 30 tablets. or 2 blisters of 15 tablets. tablets 150 mg: 20 tablets. - in a cardboard box 1 blister of 20 tablets. or 2 blisters of 10 tablets; 60 tab. - in a cardboard box there are 3 blisters of 20 tablets each. or 6 blisters of 10 tablets.
Description of the dosage form
Oval-shaped tablets with two parallel lines on both sides, white or white with a yellowish tint.
Characteristic
Triazolopyridine derivative.
Pharmacokinetics
Suction. Absorption of the drug from the gastrointestinal tract after oral administration is high. Cmax after oral administration is achieved within 1/2-2 hours. Food slows down the rate of absorption, reduces Cmax in the blood plasma and increases the time to reach it. Distribution. Penetrates through histohematic barriers, as well as into tissues and liquids (bile, saliva, breast milk). Plasma protein binding - 89-95%. Metabolism and excretion. Metabolized in the liver to form an active metabolite - 1-m-chlorophenylpiperazine. T1/2 in the first phase is 3-6 hours, in the second phase - 5-9 hours. It is excreted by the kidneys (about 75%) in the form of metabolites, with bile - about 20%. Elimination is completely completed 98 hours after taking the drug.
Pharmacodynamics
Antidepressant, triazolopyridine derivative. It has an antidepressant effect with sedative and anxiolytic effects. The mechanism of action is associated with the high affinity of the drug for certain subtypes of serotonin receptors (depending on the receptor subtype, trazodone enters into an antagonistic or agonistic interaction), as well as with the specific ability to inhibit the reuptake of serotonin. The drug has little effect on the neuronal uptake of norepinephrine and dopamine. Does not have anticholinergic effect. Trittico quickly affects mental (affective tension, irritability, fear, insomnia) and somatic (palpitations, headache, muscle pain, frequent urination, increased sweating, hyperventilation) symptoms of anxiety. Effective for sleep disorders in patients with depression: it increases the depth and duration of sleep, restores its physiological structure and quality. Stabilizes the emotional state, improves mood, reduces pathological craving for alcohol in patients suffering from chronic alcoholism during the period of alcohol withdrawal syndrome, as well as during remission. Effective in the treatment of anxiety-depressive conditions and sleep disorders during withdrawal syndrome in patients suffering from dependence on benzodiazepine derivatives. During remission, benzodiazepines can be completely replaced by trazodone. Helps restore libido and potency in both patients with depression and healthy individuals. It is not addictive and does not affect body weight.
Indications for use Trittico
Depressive states of various etiologies (endogenous, psychotic, neurotic, somatogenic, etc.) with severe anxiety and tension; pain syndrome due to neuralgia, agoraphobia, alcohol withdrawal state, drug dependence on benzodiazepines, decreased libido, impotence.
Contraindications to the use of Trittico
Hypersensitivity, myocardial infarction (early recovery period), ventricular arrhythmia, extrasystole, tachycardia, liver and/or renal failure, pregnancy, breastfeeding, age up to 6 years. With caution. Arterial hypertension (dosage adjustment of antihypertensive drugs may be required), history of priapism.
Trittico Use during pregnancy and children
Contraindicated during pregnancy. During treatment, you should stop breastfeeding. Ages up to 6 years.
Trittico side effects
From the nervous system and sensory organs: fatigue, weakness, headache, dizziness, insomnia, drowsiness, agitation, psychosis, hypomania, hallucinations, tremor, muscle twitching, grand mal seizures, aphasia, ataxia, akathisia, dyskinesia, paresthesia, confusion, syncope, blurred vision, diplopia. From the cardiovascular system and blood (hematopoiesis, hemostasis): arterial hypotension, incl. orthostatic; atrial fibrillation, arrhythmias (including tachy- and bradycardia, ectopic ventricular rhythms), congestive heart failure, leukocytosis or leukopenia, neutropenia (usually minor), hemolytic anemia, methemoglobinemia. From the gastrointestinal tract: increased appetite, dryness and discomfort taste in the mouth, hypersalivation, caries, diseases of the periodontal tissues, oral candidiasis, nausea, vomiting, flatulence, diarrhea, constipation, cholestasis, increased levels of bilirubin and amylase in the blood plasma, jaundice. From the genitourinary system: urinary retention, increased urination, hematuria, premature menstruation, hirsutism, increased libido, priapism, impotence, retrograde ejaculation. Allergic reactions: skin rash, urticaria. Other: myalgia, chest pain, alopecia, psoriasis, edema.
Drug interactions
Strengthens the effect of some antihypertensive drugs (usually requiring a reduction in their doses). When used together, it enhances the effect of drugs that depress the central nervous system (including clonidine, methyldopa). Strengthens and prolongs the sedative and anticholinergic effects of tricyclic antidepressants, haloperidol, loxapine, maprotiline, phenothiazines, pimozide and thioxanthenes. When used together, it increases the concentration of digoxin and phenytoin in the blood plasma. Antihistamines and drugs with anticholinergic activity may reveal a weak anticholinergic effect of trazodone. MAO inhibitors increase the risk of side effects.
Trittico dosage
Orally, after meals. As an antidepressant, 50 mg 3 times a day, then, depending on the type and severity of depression, the dose is gradually (50 mg every 3-4 days) increased to 300-500 mg per day (no more than 600 mg); the maintenance dose is also selected individually. As an anxiolytic, 25 mg 3 times a day. IV and IM - 50 mg for premedication.
Overdose
Symptoms: nausea, drowsiness, arterial hypotension. Treatment: Symptomatic therapy (gastric lavage, forced diuresis, etc.). There is no specific antidote.
Precautionary measures
When using trazodone, a slight decrease in the number of leukocytes is possible, which does not require specific treatment, except in cases of severe leukopenia. Therefore, it is recommended to conduct peripheral blood tests, especially if there is a sore throat when swallowing and fever. The drug does not have an anticholinergic effect, so it can be prescribed to elderly patients suffering from prostatic hypertrophy, angle-closure glaucoma, and cognitive impairment. If you experience prolonged and inadequate erections, you should consult a doctor. During treatment, you should refrain from drinking alcohol and from engaging in potentially hazardous activities that require concentration and rapid psychomotor reactions (driving a car or other machinery).
The history of my illness goes deep into childhood, but most of all it manifested itself six years ago, since then I have suffered from depression, GAD with pan-attacks and phobias, periodic insomnia and nightmares due to PTSD (and a number of its symptoms). But that's not the point. The point is, after a bunch of... The history of my illness goes deep into childhood, but most of all it manifested itself six years ago, since then I have suffered from depression, GAD with pan-attacks and phobias, periodic insomnia and nightmares due to PTSD (and a number of its symptoms).
But that's not the point. The point is that, after a bunch of drugs prescribed to me, this one, so to speak, satisfied all my requirements. Depression is gradually disappearing, my productivity has increased, the desire to create and live in general has appeared, apathy has subsided, I have become calm as a tank, for the first time in a long time I was finally able to sleep well with the lights off (yes, this was my main phobia, how could this be didn't sound like that). Side effects emerged in the form that I was taking a beta-blocker to prevent pan. attacks, and I finally removed it, since Trittiko already has the property of an alpha-blocker. Be careful with this! Low blood pressure, weakness, dizziness, palpitations and general discomfort in the heart area are obvious reasons to reduce the dosage of an adrenergic blocker of any kind, or even stop taking it altogether. Also be careful when using sedatives together, especially benzodiazepines (phenozepam, alprozalam, etc.). In principle, they are relatively easy to “get off”, thanks again to Trittico.
Advantages- Fast action;
- Effective both in the treatment of depression and anxiety disorders, or even anxiety-depressive disorder;
- Good as a sleeping pill;
- Thanks to its adrenergic blocking effect, it is possible to reduce the severity of symptoms of pan-disorder
Flaws- Not a very pleasant side effect in the form of menstrual irregularities, but I learned to live with it, because... I was told that with long-term use of such drugs this is also possible;
- Be careful when taking adrenergic blockers at the same time.
I started taking it with 1/3 of the tablet, now it’s a full tablet. Gradually increased the dose despite allergic side effects, because... The drug itself improved the psychological state. But now I’m thinking of stopping taking it: constant inflammation of the eyes, itching on the face, dry mouth in the morning, but the most unpleasant thing is that an incomprehensible cough has been added. It's a pity.
It’s a very good drug, if it doesn’t cause any side effects for you, you forget your anxieties and fears, you just gradually come to life. But I want to warn anyone who has low blood pressure - this is fraught. My blood pressure is 100/55 (+,- 10) units of the upper level. Well. as always, ah, nothing will happen. But at night I got up, didn’t have time to get there... My eyes darkened, I grabbed a can of coffee. So... It’s a very good drug, if it doesn’t cause any side effects for you, you forget your anxieties and fears, you just gradually come to life. But I want to warn anyone who has low blood pressure - this is fraught. My blood pressure is 100/55 (+,- 10) units of the upper level. Well. as always, oh, nothing will happen. But at night I got up, didn’t have time to get there... My eyes darkened, I grabbed a can of coffee. So I woke up with a can in my hand, I couldn’t understand anything, where I was and what was wrong with me - after lying down for a while, everything it has returned to normal - the pressure drops so quickly! Now I started with amitroptyline, it is still better than others. I’m thinking of switching to tritico - I don’t know the doctor’s reaction. Taking tritico constant blood pressure control And not getting out of bed right away - sit for a while Good luck!
I am 30 years old, since childhood I have been tormented by a constant feeling of anxiety, and sometimes it is impossible to do anything and the presence of fear and from this hopelessness depression sets in, I tried many antidepressants, tranquilizers, but then the doctor prescribed me Trittico I drink for 4 days 50 mg and the effect is amazing, I feel... I am 30 years old, since childhood I have been tormented by a constant feeling of anxiety, and sometimes it is impossible to do anything and the presence of fear and from this hopelessness depression sets in, I tried many antidepressants, tranquilizers, but then the doctor prescribed me Trittico I drink for 4 days 50 mg and the effect is amazing, I feel like a person again, I will continue to drink it, as much as I need and it is not addictive, as it is written in the instructions, there was not a single side effect, except for dry mouth, then I plan to do an MRI of the brain and undergo psychotherapy, to find out why I have been suffering from anxiety since childhood, I give it a 5+ trittiko!!
Trittico is a dangerous drug, and even more so if taken without a doctor’s prescription. We've all become so smart. We ourselves treat and treat children on the Internet, on forums, based on reviews. It can drive you crazy. Look for advice on forums. I had a bitter experience with the use of this Trittiko, the following came up... Trittico is a dangerous drug, and even more so if taken without a doctor’s prescription. We've all become so smart. We ourselves treat and treat children on the Internet, on forums, based on reviews. It can drive you crazy. Look for advice on forums.
I had a bitter experience with the use of this Trittico, such side effects came out that you wouldn’t wish it on your enemy. Although I drank as prescribed by the doctor. I took half a tablet and still felt bad.
I took Trittico last winter. I had trouble and a terrible depression began - I didn’t eat anything, I smoked and drank coffee, I lost 5 kg in 2 weeks, I practically didn’t sleep at night, subsequently I started having stomach pains, headaches, nausea, black circles under my eyes . All in all... I took Trittico last winter. I had trouble and a terrible depression began - I didn’t eat anything, I smoked and drank coffee, I lost 5 kg in 2 weeks, I practically didn’t sleep at night, subsequently I started having stomach pains, headaches, nausea, black circles under my eyes . In general the condition is bad. Mom sounded the alarm, first persuaded me, then tried to force me to at least eat something or go for a walk, I didn’t even go outside, I lay in bed all the time and cried. Then she told me how she gave me the drug Trittico. She dissolved the tablets in water for me. I followed the instructions strictly and on day 5 I noticed that I was in a better mood and somehow wanted to eat. And my mother told me that she gave me this Trittico. After using it I came back to life, it really helps.
pharmachologic effect
Antidepressant. Trazodone, being a triazolopyridine derivative, has a predominantly antidepressant effect, with some sedative and anxiolytic effects. Trazodone has no effect on MAO, which distinguishes it from MAO inhibitors and tricyclic antidepressants.
The mechanism of action of trazodone is associated with the high affinity of the drug for certain subtypes of serotonin receptors, with which trazodone enters into an antagonistic or agonistic interaction depending on the subtype, as well as with the specific ability to cause inhibition of serotonin reuptake.
Quickly affects mental (affective tension, irritability, fear, insomnia) and somatic symptoms of anxiety (palpitations, headache, muscle pain, frequent urination, sweating, hyperventilation).
Trazodone is effective for sleep disorders in patients with depression, increases the depth and duration of sleep, and restores its physiological structure and quality.
Trittico stabilizes the emotional state, improves mood, reduces pathological craving for alcohol in patients suffering from chronic alcoholism during the period of alcohol withdrawal syndrome, also in remission. For withdrawal symptoms in patients suffering from dependence on benzodiazepine derivatives, trazodone is effective in the treatment of anxiety, depression and sleep disorders. During remission, benzodiazepines can be completely replaced by trazodone.
Helps restore libido and potency in both depressed and non-depressed patients.
The drug is not addictive. The neutral uptake of norepinephrine and dopamine has little effect.
Does not affect body weight.
Pharmacokinetics
Suction
Absorption of the drug from the gastrointestinal tract after oral administration is high. Taking trazodone during or immediately after a meal slows down the rate of absorption, reduces Cmax of the drug in the blood plasma and increases Tmax. Cmax in blood plasma is reached 0.5-2 hours after oral administration.
Distribution
Plasma protein binding – 89-95%. Penetrates through histohematic barriers, as well as into tissues and liquids (bile, saliva, breast milk).
Metabolism
Trazodone is metabolized in the liver, the active metabolite is 1-m-chlorophenylpiperazine.
Removal
T1/2 is 3-6 hours, in the second phase - 5-9 hours. Most of the metabolites are excreted by the kidneys - about 75%, and elimination is completely completed 98 hours after administration; About 20% is administered with bile.
Indications
— anxiety-depressive states of endogenous nature (including involutional depression);
— psychogenic depression (including reactive and neurotic depression);
— anxiety-depressive states against the background of organic diseases of the central nervous system (dementia, Alzheimer’s disease, cerebral atherosclerosis);
— depressive states with long-term pain syndrome;
- alcoholic depression;
- benzodiazepine dependence;
— libido and potency disorders, incl. for depressive conditions.
Dosage regimen
The drug is taken orally 30 minutes before meals or 2-4 hours after meals. The prescribed dose of the tablet should be taken whole, without chewing and with a sufficient amount of water.
For adults prescribed at an initial dose of 100 mg 1 time/day after meals before bedtime. On the 4th day you can increase the dose to 150 mg. Subsequently, in order to achieve the optimal therapeutic effect, the dose is increased by 50 mg/day every 3-4 days until the optimal dose is reached. A daily dose of more than 150 mg should be divided into 2 doses, with the smaller dose taken after lunch and the main dose before bed.
The maximum daily dose for outpatients is 450 mg.
The maximum daily dose for inpatients is 600 mg.
At treatment of impotence, in the case of monotherapy with the drug, the recommended daily dose is more than 200 mg, with combination therapy - 50 mg.
At treatment of benzodiazepine addiction The recommended treatment regimen is based on a gradual, sometimes over several months, reduction of the benzodiazepine dose. Each time, reducing the dose of benzodiazepine by 1/4 or 1/2 tablet, 50 mg of trazodone is simultaneously added. This ratio is left unchanged for 3 weeks, then a further gradual reduction in the dose of benzodiazepines is started until they are completely discontinued. After this, reduce the daily dose of trazodone by 50 mg every 3 weeks.
For
Children aged 6-18 years: initial daily dose of 1.5–2 mg/kg/day, divided into several doses. If necessary, the dose is gradually increased to 6 mg/kg/day at intervals of 3-4 days.
Side effect
From the central nervous system and peripheral nervoussystems: increased fatigue, drowsiness, agitation, headache, dizziness, weakness, myalgia, incoordination, paresthesia, disorientation, tremor.
From the cardiovascular system: decreased blood pressure, orthostatic hypotension (especially in individuals with vasomotor lability) due to the adrenolytic effect of the drug, arrhythmia, conduction disturbances, bradycardia, leukopenia and neutropenia (usually minor).
From the digestive system: dry and bitter mouth, nausea, vomiting, diarrhea, loss of appetite.
Others: allergic reactions, eye irritation, priapism (patients who experience this side effect should immediately stop taking the drug and consult a doctor).
Contraindications for use
- pregnancy;
- lactation period;
- children under 6 years of age;
- hypersensitivity to the components of the drug.
WITH caution the drug should be prescribed to patients with AV block, myocardial infarction (early recovery period), arterial hypertension (dose adjustment of antihypertensive drugs may be required), ventricular arrhythmia, a history of priapism, renal and/or liver failure, patients under 18 years of age .
Use during pregnancy and breastfeeding
The drug is contraindicated for use during pregnancy and lactation (breastfeeding).
Use in children
Contraindication: children under 6 years of age. WITH caution The drug should be prescribed to patients under 18 years of age.
Overdose
Symptoms: nausea, drowsiness, hypotension, increased frequency and severity of side effects.
Treatment: There is no specific antidote for the drug. In cases of overdose, symptomatic treatment is carried out (including gastric lavage, forced diuresis).
Drug interactions
Trazodone may enhance the effect of some antihypertensive drugs and dose reductions are usually required.
Simultaneous administration with drugs that depress the central nervous system (including clonidine, methyldopa) enhances the effect of the latter.
Antihistamines and drugs with anticholinergic activity enhance the anticholinergic effect of trazodone.
Trazodone enhances and prolongs the sedative and anticholinergic effects of tricyclic antidepressants, haloperidol, loxapine, maprotiline, phenothiazine, pimozide and thioxanthene.
MAO inhibitors increase the risk of side effects from trazodone.
When used together, it increases the concentration of digoxin and phenytoin in the blood plasma.
Conditions for dispensing from pharmacies
The drug is available with a prescription.
Storage conditions and periods
The drug should be stored out of the reach of children at a temperature not exceeding 25°C. Shelf life - 3 years.
Use for liver dysfunction
The drug should be prescribed with caution to patients with liver failure.
Use for renal impairment
The drug should be prescribed with caution to patients with renal failure.
Use in elderly patients
For elderly and frail patients initial dose - up to 100 mg/day in fractional doses or 1 time/day before bedtime. The dose may be increased under medical supervision, depending on the effectiveness and tolerability of the drug. Usually no dose exceeding 300 mg/day is required.
special instructions
Since the drug has some adrenolytic activity, bradycardia and a decrease in blood pressure may develop. Therefore, the drug should be prescribed with caution to patients with cardiac conduction disorders, AV block of varying severity, and patients with recent myocardial infarction.
When using trazodone, a slight decrease in the number of leukocytes is possible, which does not require specific treatment, except in cases of severe leukopenia. Therefore, during the treatment period, it is recommended to conduct peripheral blood tests, especially in the presence of pain in the throat when swallowing and the appearance of fever.
The drug does not have an anticholinergic effect, so it can be prescribed to elderly patients suffering from prostatic hypertrophy, angle-closure glaucoma, and cognitive impairment.
If prolonged and inadequate erections occur, the patient should consult a doctor.
During the treatment period, the patient must abstain from drinking alcohol.
Impact on the ability to drive vehicles and operate machinery
Since the drug has anxiolytic and sedative activity, a decrease in the ability to concentrate and the speed of psychomotor reactions is possible. During treatment, the patient should avoid engaging in potentially hazardous activities, incl. driving vehicles and operating machinery.
Trittico is an antidepressant from the triazolopyridine group, used to treat various depressive disorders. Active ingredient: Trazodone.
The mechanism of action of trazodone is due to the high affinity of the drug for certain subtypes of serotonin receptors. It is with these subtypes of serotonin receptors that trazodone enters into agonistic or antagonistic interaction.
The drug has anxiolytic activity and has a sedative effect. Trazodone eliminates the pathogenetic cause of depression - lack of serotonin, due to this it has an antidepressant effect, eliminates affective tension, removes feelings of fear, and speeds up falling asleep.
Trittico effectively removes tachycardia, headache, myalgia and other somatic symptoms of increased anxiety, and restores sleep. During therapy, there is stabilization of the emotional state, a decrease in craving for alcohol during withdrawal syndrome, and easier withdrawal from benzodiazepines during remission.
The drug is used with caution in case of heart disease, arterial hypotension, arterial hypertension, renal and/or liver failure. During treatment you should refrain from drinking alcohol.
Indications for use
What is Trittiko used for? According to the instructions, the drug is prescribed in the following cases:
- anxiety-depressive states of endogenous nature (including involutional depression);
- psychogenic depression (including reactive and neurotic depression);
- anxiety-depressive states against the background of organic diseases of the central nervous system (dementia, Alzheimer's disease, cerebral atherosclerosis);
- depressive states with prolonged pain syndrome;
- alcoholic depression;
- benzodiazepine dependence;
- libido and potency disorders (including erectile dysfunction in depressive states).
Instructions for use of Trittico, dosage
It is advisable to take the tablets a few hours after meals. The usual time of administration is before bedtime.
The initial daily dosage is 1-2 Trittico 50 mg tablets, taken in one dose before bedtime. Then the dose can be increased to 150-200 mg, which must be divided into 3 doses.
For mild forms of depression, the average maintenance dose is 1 Trittico 150 mg tablet once a day. For moderate and severe forms – 300 mg/day.
If necessary, the dose can be increased to 600 mg per day. It is recommended to take the main portion before bedtime.
To treat libido – 50 mg per day, and to improve erectile function – 150-200 mg per day.
- The maximum daily dose for outpatients is 450 mg.
- The maximum daily dose for inpatients is 600 mg.
Therapy for dependence on benzodiazepine drugs consists of slowly increasing the doses of trazodone in parallel with reducing the doses of benzodiazepines in the following ratio: for every increase in the daily dosage of the drug by 50 mg, the dose of the benzodiazepine is reduced by a quarter of a tablet.
This recalculation of dosages is carried out every three weeks. After the moment when the benzodiazepine dosage is zero, treatment is continued with a reduction in trazodone doses. The daily dose of Trittico is reduced by 50 mg every three weeks.
Side effects
The instructions warn about the possibility of developing the following side effects when prescribing Trittico:
- from the nervous system – fatigue, dizziness, agitation, headache, myalgia, weakness, paresthesia, tremor;
- from the circulatory and hematopoietic systems - orthostatic hypotension, bradycardia, decreased pressure, conduction disturbances, arrhythmia; neutropenia and leukopenia;
- from the digestive system - nausea, dry mouth, diarrhea;
- others – eye irritation, allergic reactions.
Contraindications
Trittico is contraindicated in the following cases:
- chronic alcoholism;
- poisoning with alcohol or sleeping pills;
- pregnancy and breastfeeding;
- age under 18 years;
- individual intolerance to the drug.
Prescribed with caution in the following conditions:
- atrioventricular block;
- recent myocardial infarction (less than 3 months ago);
- ventricular type cardiac arrhythmia;
- renal or liver failure;
- arterial hypertension.
Overdose
Signs of overdose are clinically expressed by increased side effects, arterial hypotension, coma, cardiac and vascular disorders, and severe bradycardia.
If symptoms of overdose appear, you should stop taking the medication and consult a doctor. Treatment of overdose consists of gastric lavage, administration of enterosorbents and symptomatic therapy.
Trittico analogues, price in pharmacies
If necessary, you can replace Trittiko with an analogue for therapeutic action - these are the following drugs:
- Glycised;
- Pantogam.
By ATX code:
- Azona.
When choosing analogues, it is important to understand that the instructions for use of Trittico, the price and reviews of drugs with similar effects do not apply. It is important to consult a doctor and not change the drug yourself.
Price in Russian pharmacies: Trittiko tablets 150 mg 20 pcs. – from 625 to 670 rubles.
Store in a dark place at a temperature not exceeding 25 ⁰C. Shelf life – 3 years. Sales in pharmacies with a doctor's prescription.
Why is the medicine "Trittico" prescribed? Let's take a closer look in this article.
Depression is a mental disorder characterized by disturbances in thinking, motor retardation and decreased mood. Many people do not classify depression as a disease and do not consider it dangerous, but this is a common misconception. This is a serious and dangerous mental pathology that causes passivity and depression in a person.
Signs of pathology
Characteristic signs of depression are decreased self-esteem, apathy and deep indifference to your life and the world around you. Quite often, a depressed person develops an addiction to alcohol and drugs. However, this method does not solve the problem and does not remove the cause of depression, but only relieves the symptoms. In addition, the use of alcohol and drugs aggravates a person’s mental state, making him lost.
Depression as a mental disorder can be found more often among women; men rarely become victims of this disease. People between 18 and 55 years of age are at greatest risk of becoming depressed, but in rare cases, the onset of the disorder may occur earlier or later.
Kinds
The disease is divided into certain types depending on the reasons for its occurrence:
It is necessary to treat depressive disorders, as the lack of help can lead to consequences in the future. This will not only seriously affect a person’s overall health, but can also develop into more serious mental pathologies. The pharmaceutical market offers a wide selection of drugs aimed at treating and relieving symptoms of depression. Among them, doctors often prescribe Trittico, an antidepressant trazodone, a triazolopyridine derivative. The drug creates an antidepressant effect, simultaneously having an anxiolytic and sedative effect on the body. Reviews about "Trittico" abound.
Mechanism of action
Unlike tricyclic antidepressants and MAO inhibitors, trazodone does not affect monoamine oxidase. The action of trazodone is due to the high degree of affinity of the drug for certain types of serotonin receptors. Trazodone interacts with them agonistically or antagonistically, and also has the ability to cause serotonin reuptake blocking. This is confirmed by the instructions attached to the drug "Trittico".
The drug has a rapid effect on symptoms of mental and physical anxiety, such as irritability, insomnia, fear, affective tension, headaches, palpitations, frequent urination, hyperventilation, sweating and muscle pain.
"Trittico" effectively relieves sleep disorders, increasing its duration and depth, as well as positively influencing its quality and physiological structure. In addition, in chronic alcoholics during the period of abstinence, the drug is able to normalize the emotional background, elevate mood, and reduce cravings for alcohol. The drug is effective in the treatment of depressive disorders in patients who are dependent on benzodiazepine derivatives. During the remission period, trazodone should completely replace benzodiazepines. Another effect of the drug is to increase potency and libido. Moreover, patients who do not suffer from depressive disorders can use the drug for this purpose.
According to reviews, Trittiko does not become addictive. It does not affect dopamine and norepinephrine uptake or weight gain.
Compound
One tablet contains 150 mg of trazodone hydrochloride and excipients (sucrose, lovidone, carnauba wax and magnesium sterate).
The drug has a high degree of absorption from the gastrointestinal tract. The drug cannot be used with food or immediately after, as this slows down absorption. The active substance is metabolized in the liver. 75 percent of metabolites are excreted through the kidneys. Complete elimination of the drug from the body occurs within 98 hours after administration.
Indications
Indications for prescribing Trittico tablets are:
- Anxiety and depressive disorders of endogenous type. This also includes involutional depression.
- Neurotic and reactive psychogenic depression.
- Depressive disorders as a consequence of pathologies of the central nervous system: atherosclerosis, Alzheimer's disease, dementia, etc.
- Depression due to prolonged pain syndrome.
- Alcohol-related depressive disorders.
- Violations of potency and libido, including against the background of depression.
- Benzodiazepine addiction.
Side effects
According to reviews, the following conditions may be side effects from taking Trittico:
- Drowsiness.
- Fast fatiguability.
- Headache.
- Nervous excitement.
- Dizziness.
- Myalgia.
- Weakness.
- Discoordination.
- Disorientation.
- Tremor.
- Paresthesia.
- Reduced blood pressure.
- Arrhythmia.
- Orthostatic hypotension as a consequence of the adrenolytic effect of taking the drug.
- Bradycardia.
- Neutropenia and leukopenia.
- Conduction disturbance.
- Feeling of bitterness in the mouth and dryness.
- Diarrhea.
- Nausea and vomiting.
- Allergic reactions.
- Decreased appetite.
- Eye irritation.
- Priapism.
The appearance of these symptoms is a reason to stop taking the drug and consult your doctor.
Contraindications
According to the instructions, Trittico is contraindicated in the following cases:
- Pregnancy and lactation.
- Children under 6 years of age.
- Individual intolerance to the components of the drug.
The drug should be prescribed to children under 18 years of age with the utmost caution. For elderly and debilitated patients, it is necessary to select an individual dosage regimen. Starting with a minimum dose, it can be increased depending on how the patient’s body responds to therapy. Typically, a sufficient daily dose of Trittico tablets is 300 mg.
Instructions for use
"Trittiko" is produced in the form of tablets of 75 and 150 mg.
The drug is taken orally half an hour before meals or at least two hours after. The tablet must not be chewed; it must be swallowed whole and washed down with plenty of clean water.
For adult patients, at the beginning of treatment, a single dose of 100 mg is prescribed immediately before going to bed. Starting from the fourth day of therapy, the dosage can be increased to 150 mg. To achieve the maximum effect of therapy with Trittico, the daily dosage should be increased by 50 mg every 4 days until it reaches 300 mg. Starting from 150 mg, the dose should be divided into two times. Most of it is taken before bed, and the smaller part is taken after lunch. For outpatients, the maximum daily dosage is increased to 450 mg; for inpatients, it can be 600 mg.
For the treatment of decreased libido, the daily dosage is 50 mg. In the case of monotherapy in the treatment of impotence, it is recommended to take 200 mg per day, with combination therapy - 50 mg.
Therapy for benzodiazepine addiction involves a specific treatment regimen based on a gradual reduction in the dose of benzodiazepine and replacing it with the antidepressant Trittico. Reducing the benzodiazepine dosage by ½ tablet, add 50 mg of trazodone. Then nothing changes for three weeks, then the benzodiazepine reduction continues until it is completely discontinued. Once this point is reached, trazodone is tapered off at 50 mg every three weeks.
The initial daily dosage for older people is 100 mg. It can be taken once before bed or divided into two doses. Increasing the dosage should only occur under the supervision of a physician. Most often, there is no need for a daily dosage of more than 300 mg.
Children aged 6 to 18 years are prescribed up to 2 mg per kilogram of body weight per day. Reception is divided into several times a day. It is possible to increase the dosage to 6 mg per kilogram per day.
Interaction with other drugs
Trittico reduces the effect of certain antihypertensive drugs, which may require a reduction in their dosage.
The effects of drugs such as methyldol and clonidine, which can depress the central nervous system, are also enhanced when taken simultaneously with trazodone.
Drugs with antihistamine action and anticholinergic activity increase the effectiveness of taking trazodone.
Trittico and alcohol are incompatible. This leads to hypoxia and deterioration in general well-being.
The drug prolongs and enhances the anticholinergic and sedative effect of tricyclic antidepressants, loxapine, haloperidol, phenothiazine, thioxanthene, limozide and maprotiline.
Concomitant use of trazodone with MAO inhibitors significantly increases the risk of adverse reactions. This combination, among other things, increases the accumulation of phenytoin and digoxin in the blood plasma.
The drug also interacts with substances such as ritonavir, indinavir, ketoconazole and fluoxetine. These components increase the concentration of trazodone in the blood. Analogues of the drug Trittico should be selected by a doctor.
special instructions
Since the drug is capable of exhibiting certain adrenolytic activity, bradycardia may occur while taking it, as well as a decrease in blood pressure. For this reason, its prescription to patients with cardiovascular problems should be done with an assessment of possible risks. The same applies to patients with recent myocardial infarction, cardiac conduction disorders and AV block of varying severity.
Taking Trittico may cause a slight decrease in the level of leukocytes in the blood, but this phenomenon does not require special treatment unless it reaches the level of pronounced leukopenia.
During the course of therapy with this drug, microbiological blood tests should be performed regularly, especially if you have a sore throat or fever. The side effects of Trittico are described in detail above.
The drug has no anticholinergic effect. Therefore, it can be taken by older people who have a history of prostatic hypertrophy, cognitive impairment, or angle-closure glaucoma.
Available only by prescription. Unreasonable or too long erections are a reason to consult a doctor. Alcohol consumption is prohibited during therapy.
Since the drug has an anxiolytic and sedative effect, a decrease in attention and speed of psychomotor functions may occur. Therefore, for the duration of therapy, it is better to refrain from driving vehicles, operating high-precision mechanisms and other dangerous activities.